Kansas City Royals vs Los Angeles Angels Picks & Predictions for Thursday, September 25, 2025

By: Kim Smith Published 09/25/2025, 12:05 AM ET
Use Code PPWC

The Kansas City Royals (79-78, 2nd in AL Central) face the Los Angeles Angels (70-87, 4th in AL West) in the finale of a three-game series at Angel Stadium, with the Royals fighting to stay in the AL wild-card race. All eyes are on Bobby Witt Jr. for Kansas City and Taylor Ward for the Angels, as their performances could dictate this game’s outcome. Our free MLB picks spotlight these stars to uncover the best betting angles for this crucial matchup.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No
Video: World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
Video: Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026
Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026

Game Details

  • Date: September 25, 2025
  • Time: 9:38 PM EDT
  • Venue: Angel Stadium, Anaheim, California
  • Broadcast Info: MLB Network (national), Bally Sports Kansas City (Royals broadcast), Bally Sports West (Angels broadcast)
  • Weather: 71Β°F, clear skies, 5-8 mph winds blowing out to centerβ€”slightly favoring hitters.

Spotlight Player(s)

  • Kansas City Royals: Bobby Witt Jr. (SS): Witt (.295 AVG, 31 HR, 110 RBI) is the Royals’ heartbeat, hitting .340 with 4 HR over his last 10 games. Against the Angels in 2025, he’s 6-for-14 with 2 HR and 5 RBI, thriving against left-handers like Yusei Kikuchi (.360 AVG). His speed (32 SB) and power (.506 SLG) make him a multi-faceted threat.
  • Los Angeles Angels: Taylor Ward (LF): Ward (.265 AVG, 22 HR, 102 RBI) leads the Angels’ offense, going 8-for-33 with 3 HR in his last 10 games. He’s 4-for-10 against the Royals this season with a homer, showing his knack for clutch hits against right-handers like Stephen Kolek. His .470 SLG at home is a key factor.
  • Impact: Witt’s all-around dominance could spark the Royals’ wild-card push, while Ward’s power at Angel Stadium keeps the Angels competitive in a hitter-friendly park.

Supporting Cast & Depth

  • Royals: Vinnie Pasquantino (31 HR, 108 RBI) and Maikel Garcia (.285 AVG, 36 2B) bolster the lineup, with Pasquantino’s 5 RBI in the series (9/23-9/24) proving his worth. The bullpen (3.64 ERA, 41 saves) is reliable but taxed after recent close games, with Lucas Erceg (3.20 ERA) as the go-to closer. Injuries to Cole Ragans (shoulder) and Hunter Harvey (forearm) limit pitching depth.
  • Angels: Nolan Schanuel (.268 AVG, .350 OBP) and Zach Neto (.261 AVG, 25 HR) provide offensive support, but the Angels’ bullpen (4.43 ERA) struggles, with Reid Detmers (3 saves) offering some stability. Injuries to Mike Trout (knee) and JosΓ© Soriano (arm) weaken their roster.
  • Edge: Royals’ deeper lineup and stronger bullpen outmatch the Angels’ depleted pitching staff, but Los Angeles’ home bats keep them in games.

Betting Line Breakdown

  • Moneyline: Royals +100 (50%), Angels -120 (55%)
  • Run Line: Royals +1.5 (-215, ~68%), Angels -1.5 (+170, ~37%)
  • Total: Over 8.5 (-110, ~52%), Under 8.5 (-110, ~52%)
  • Player Influence: Witt’s hot streak could push the Royals to an upset or cover, while Ward’s power at home supports the Angels’ slight favorite status and the over. The Angels’ pitching vulnerabilities (4.51 ERA) give Royals’ bats, led by Witt, a chance to drive up the score.

Picks For Royals vs Angels

  1. Bobby Witt Jr. Over 1.5 Hits + Runs + RBI (-105): Witt’s .295 AVG and .360 clip against lefties like Kikuchi make this a prime prop. His 6-for-14 mark with 2 HR against the Angels this season, combined with his recent form (14-for-41), ensures multiple contributions in a hitter-friendly park.
  2. Royals Moneyline (+100): The Royals’ superior offense (.245 AVG, .698 OPS vs. Angels’ .226 AVG, .696 OPS) and bullpen (3.64 ERA vs. 4.43) give them upset potential. Kolek’s 3.54 ERA outshines Kikuchi’s 4.05, and Kansas City’s 4-3 record in the 2025 series favors them as slight underdogs.
  3. Over 8.5 Total Runs (-110): Angel Stadium’s conditions and the Angels’ weak pitching (4.51 ERA, 1.44 WHIP) suggest runs. Witt and Pasquantino exploit Kikuchi’s 1.35 WHIP, while Ward and Neto target Kolek’s average command. Four of the last six Royals-Angels games cleared 8.5 runs, supporting the over.
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.