Los Angeles Angels vs Houston Astros Picks and Predictions, for Monday, September 1, 2025

By: David Anicetti Updated 09/01/2025, 01:34 PM ET

On Monday, the Los Angeles Angels complete a four-game series on the road versus the Houston Astros. Los Angeles is 63-72 following Saturday’s  4-1 victory over the Astros. Oswald Peraza hit a ninth-inning two-run single to help lead Los Angeles to the victory. The win snapped a three-game losing streak for the Angels. Los Angeles trails first place in the American League West by 11.5 games and is 8.5 games behind the third and final AL wild card spot. Keep up to date with all the MLB action with our MLB picks.

Zach Neto is batting .267 to lead Los Angeles, while Nolan Schanuel is the leader in hits with 123. Taylor Ward leads in home runs with 30 and RBI with 94, while Mike Trout is the leader in on-base percentage at .361.  Los Angeles is batting .229 with a .402 slugging percentage. On Monday, Los Angeles will send Yusei Kikuchi to the mound. The left-hander is 6-9 with a 3.68 ERA, 156 Ks, and 64 BBs.

The Houston Astros are 75-61 following Saturday’s three-run loss to Los Angeles, snapping a three-game winning streak by the Astros. Houston is just 22nd in runs scored, while on the mound, the Astros are a respectable ninth in ERA. Houston holds a three-game lead over the second-place Seattle Mariners at the top of the American League West.

Jeremy Pena is batting .307 with an on-base percentage of .365 to lead Houston in both categories. Jose Altuve is the leader in home runs with 23 and hits with 139, while Christian Walker leads in RBI with 74. Houston is batting .253 with a .401 slugging percentage. Houston has not announced its starting pitcher for the final game of a four-game series at home versus Los Angeles.

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  • Los Angeles is 2-6 in its last 8
  • The OVER has cashed in 7 of the Angels’ last 11 vs an AL opponent
  • Houston is 6-3 in its last 9
  • The UNDER has cashed in each of the Astros’ last 6

Angels vs Astros Prediction

Los Angeles has won just two of its last eight games overall, and the Angels have lost 10 of the last 14 played on the road. Houston has won 11 of the last 15 head-to-head versus Los Angeles, and the Astros have won 13 of the last 20 played at home versus the Angels. Los Angeles starter Yusei Kikuchi was hit hard last time out, allowing six runs on four hits across four innings, resulting in a 7-3 loss to Texas. Final Score Prediction: Houston Astros win 7-2.

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