Los Angeles Angels vs Seattle Mariners Picks and Prediction for Friday September 12 2025

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Mariners vs Angels Game Information

The Seattle Mariners continue their home series with the Los Angeles Angels in town on Friday. The Mariners are a heavy -165 home favorite and the total is set at 7.5 runs. The Angeles beat the Mariners 4-1 in their last meeting back in July. Check out all of our experts MLB Free Picks.

Seattle Mariners Preview

The Seattle Mariners entered this series on Thursday riding a five game win streak. The Mariners are 44-27 at home and have won six of their last ten games. Seattle swept St. Louis in their last series. The Mariners outscored the Cardinals 13-7 in that series. Seattle is averaging 8.3 hits per game.

Luis Castillo will make his 30th start on the mound for the Mariners. Castillo is 9-8 on the season with 161.1 innings pitched. Castillo has 144 strikeouts and carries a 3.85 ERA. Castillo pitched 6 innings in his last start allowing 4 hits and 1 run.

Los Angeles Angels Preview

The LA Angels also entered this series riding a win streak. The Angels won two straight entering Thursday's matchup. Los Angeles has won five of their last ten games and carry a losing road record. The Angels are averaging 7.6 hits per game.

Yusei Kikuchi will make his 31st  start on the mound for the LA Angels. Kikuchi is 6-11 on the season with 161.2 innings pitched. Kikuchi has 163 strikeouts and carries a 4.18 ERA. Kikuchi pitched 2 innings in his last start allowing 6 hits and 7 runs.

Seattle Mariners vs Los Angeles Angels Pick and Predictions:

Final Score Prediction: Seattle Mariners win 6-3.

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Mariners vs Angels Best Free Picks:

• Seattle Mariners -1.5 runs
• OVER 7.5