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Los Angeles Dodgers vs Baltimore Orioles Picks and Predictions for Saturday, September 6, 2025

By: David Anicetti Published 09/06/2025, 12:25 AM ET

The Los Angeles Dodgers visit the Baltimore Orioles on Saturday at Camden Yards for the second game of a three-game series, with the first pitch set for 5:05 PM ET. Los Angeles enters at 78-62, leading the NL West by just two games, and has three straight losses. Baltimore sits at 64-76 and out of the race, but the Orioles have won four of the last five, including a series win in San Diego. With Yoshinobu Yamamoto facing Trevor Rogers, bettors should look at our MLB picks.

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Los Angeles Dodgers Preview

Los Angeles turns to Yoshinobu Yamamoto, who has been one of the most reliable arms in their rotation. He has a record of 11–8 with a 2.82 ERA, 1.05 WHIP, and 167 strikeouts in 146.2 innings. He has limited homers to 13 and consistently works deep into games. The Dodgers’ offense is powered by Shohei Ohtani, who has launched 46 home runs with 87 RBI and a .279 average. Freddie Freeman has a team-best .294 batting average and 139 hits, while Mookie Betts continues to contribute with 15 homers and 61 RBI.

Despite that talent, Los Angeles has slumped recently. They have dropped five of the last seven, scoring just 10 total runs in the Pittsburgh series. As a team, they are batting .252 with 205 home runs, but the timing of hits has been an issue. The pitching staff has a 4.13 ERA and 1.29 WHIP.

Baltimore Orioles Preview

Baltimore counters with Rogers, who has been lights-out this season. The left-hander is 8-2 with a 1.39 ERA and 0.82 WHIP through 90.1 innings. He has struck out 81 while allowing just three home runs, while playing for a team that gives him little run support. Gunnar Henderson leads with a .278 average, 16 homers, and 61 RBI. Colton Cowser and Adley Rutschman have provided key hits, but the overall production is average, with the team sitting at .242 with 170 home runs.

 Orioles vs Dodgers Prediction

This matchup sets up as a duel between a solid Dodgers lineup and one of the hottest pitchers in baseball. Los Angeles will test Rogers’ ability, while Baltimore needs Henderson and the supporting bats to capitalize on Yamamoto’s occasional command lapses.

Final Score Prediction: Dodgers 4, Orioles 2

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Orioles vs Dodgers Best Picks:

  • Under 8 runs - both starters limit opposing lineups' run chances.
  • Dodgers moneyline - the Dodgers have struggled but Baltimore traded away its best power hitters at the deadline.
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