Los Angeles Dodgers vs San Diego Padres Picks and Prediction for Wednesday May 20 2026
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The Los Angeles Dodgers travel to face the San Diego Padres on Wednesday May 20, 2026, at Petco Park in San Diego, California. First pitch is scheduled for 8:40 PM ET with television coverage on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.
Starting Pitchers
Shohei Ohtani is expected to start for Los Angeles in this matchup. The right-hander enters with a 3-2 record, a remarkable 0.82 ERA, and a 0.82 WHIP across 44.0 innings pitched. He has allowed only 25 hits while recording 50 strikeouts and issuing 11 walks while surrendering just two home runs. San Diego is expected to counter with Randy Vasquez, who enters with a 5-1 record, a 2.68 ERA, and a 1.11 WHIP over 50.1 innings. He has allowed 43 hits while striking out 45 batters and walking 13 while allowing four home runs.
Dodgers Attempting to Rebound After Tight Loss
Los Angeles enters Wednesday with a 29-19 overall record and a 14-9 road record. The Dodgers recently lost to San Diego 1-0 after recently winning over the Angels by scores of 10-1, 15-2, and 6-0. Los Angeles also recently won over San Francisco 5-2 during this strong stretch. The Dodgers have won four of their last five games despite the narrow loss in the series opener.
The Dodgers are batting .262 as a team with 248 runs scored and 422 hits this season. Los Angeles has hit 62 home runs while posting a .344 on-base percentage and a .428 slugging percentage. On the mound, the Dodgers own a 3.17 ERA and a 1.10 WHIP while limiting opponents to a .211 batting average. The pitching staff has recorded 431 strikeouts while issuing 135 walks this season.
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One major strength for Los Angeles entering this matchup is overall balance. The Dodgers hold advantages in batting average, runs scored, hits, home runs, on-base percentage, slugging percentage, ERA, WHIP, and opponent batting average compared to San Diego. Los Angeles has also been dominant offensively during recent games, scoring at least five runs in four of the last five contests.
Padres Looking to Continue Strong Run
San Diego enters Wednesday with a 29-18 overall record and a 14-10 home record. The Padres recently won over Los Angeles 1-0 after recently winning over Seattle by scores of 8-3, 7-4, and 2-0. San Diego also recently lost to Milwaukee 7-1 before beginning this current winning stretch. The Padres have now won four straight games entering Wednesday night.
San Diego is batting .223 as a team with 196 runs scored and 343 hits this season. The Padres have hit 47 home runs while posting a .294 on-base percentage and a .369 slugging percentage. On the mound, San Diego carries a 3.93 ERA and a 1.24 WHIP while opponents are batting .233 against the pitching staff. The Padres have recorded 413 strikeouts and issued 158 walks this season.
One key strength for San Diego entering this matchup is recent pitching form. The Padres have allowed only one total run during the current four-game winning streak and recently shut out Los Angeles in the series opener. However, San Diego still trails the Dodgers in most offensive categories entering Wednesday’s contest.
Los Angeles Dodgers vs San Diego Padres Picks and Prediction
Los Angeles Dodgers vs San Diego Padres Pick
- Pick: Los Angeles Dodgers Moneyline
Los Angeles enters this matchup with stronger overall numbers on both sides of the ball and one of the best starting pitching matchups available Wednesday. The Dodgers hold advantages in nearly every major offensive category while also carrying the better ERA, WHIP, and opponent batting average. Shohei Ohtani has been outstanding this season with a 0.82 ERA and a 0.82 WHIP, and Los Angeles had won four straight games before the 1-0 loss in the opener. With the stronger overall statistical profile, the Dodgers appear positioned to bounce back.
Los Angeles Dodgers vs San Diego Padres Total Pick
- Pick: Take the under if the total is set at 7.5
I would lean toward the under because both starting pitchers enter with excellent ERA numbers and both teams recently played a 1-0 game in the series opener. Los Angeles carries a 3.17 team ERA while San Diego has allowed only one total run during its four-game winning streak. Both projected starters have WHIP numbers close to or below 1.10, and this matchup profiles as another tightly contested pitching battle.
Final Score Prediction: Los Angeles Dodgers 4 – San Diego Padres 2
This prediction was written before the completion of game play on Tuesday.
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