Los Angeles Dodgers vs San Francisco Giants Picks and Predictions for Wednesday April 22 2026
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The Los Angeles Dodgers and San Francisco Giants are set to meet at Oracle Park in San Francisco, California on Wednesday, April 22, 2026, with first pitch scheduled for 9:45 PM and coverage available on MLB.TV. The betting odds list Los Angeles as a -199 favorite on the moneyline, while San Francisco comes in at +163. The total is set at 7.5 runs, with the over priced at -115 and the under at -105. On the run line, the Dodgers are -1.5 at -115, while the Giants are +1.5 at -105. Make sure to check out our free MLB picks.
Starting Pitchers Headline the Matchup
Shohei Ohtani takes the mound for Los Angeles, entering with a 2-0 record, a dominant 0.50 ERA, and a 0.72 WHIP over 18.0 innings. He has allowed just 7 hits while striking out 18 and walking 6, without surrendering a home run. On the other side, Tyler Mahle will start for San Francisco, carrying a 0-3 record, a 7.23 ERA, and a 1.93 WHIP across 18.2 innings. He has allowed 24 hits, recorded 21 strikeouts, walked 12, and given up 6 home runs. 
Dodgers Bringing Strong Form into Rivalry Clash
Los Angeles enters this matchup with a 16-6 record and a 7-3 mark on the road. The Dodgers have shown strong form over their last five games, recently winning over Colorado 12-3 and also securing victories in that stretch, including a 7-1 result and an 8-2 win against New York. They also recently lost to Colorado twice, but overall, their recent play reflects a team that has been competitive and capable of producing runs consistently.
From a statistical standpoint, Los Angeles is hitting .293 with 133 runs, 222 hits, and 42 home runs. The Dodgers have posted a .366 on-base percentage and a .507 slugging percentage. On the pitching side, they carry a 3.42 ERA and a 1.12 WHIP, while limiting opponents to a .211 batting average. The staff has recorded 183 strikeouts and issued 67 walks.
One of the most significant strengths for Los Angeles is its offensive production. The high batting average, strong slugging percentage, and 42 home runs highlight a lineup that has been able to generate runs at a consistent and impactful level.
Giants Hoping to Find Consistency at Home
San Francisco comes into this contest with a 9-13 record and a 3-7 mark at home. The Giants have had mixed results over their last five games, recently losing to Washington 3-0 but also picking up wins in that stretch, including a 7-6 extra-inning victory and a 10-5 result. They also recently won over Cincinnati but lost another game in that same series, showing inconsistency in recent performances.
Offensively, San Francisco is hitting .251 with 75 runs, 190 hits, and 13 home runs. The Giants have posted a .293 on-base percentage and a .365 slugging percentage. On the pitching side, they hold a 4.15 ERA and a 1.32 WHIP, while allowing opponents to hit .237. The staff has recorded 195 strikeouts and issued 84 walks.
A key concern for San Francisco is its run production. Despite a solid batting average, the lower total of runs scored and home run output suggests that the offense has not been as impactful as other teams in generating consistent scoring.
Los Angeles Dodgers vs San Francisco Giants Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bruce Marshall | +5,209.00 |
| 2 |  Bryan Power | +5,050.00 |
| 3 |  Tony Karpinski | +3,550.00 |
| 4 |  Chip Chirimbes | +2,263.00 |
| 5 |  The Gold Sheet | +1,907.00 |
Los Angeles Dodgers vs San Francisco Giants Pick
Pick: Los Angeles Dodgers -1.5
Los Angeles enters this matchup with clear advantages in both pitching and offense. The Dodgers’ lineup has been producing at a high level, while their pitching staff has maintained strong efficiency. With a significant gap in pitching metrics between the starters and overall team production favoring Los Angeles, the Dodgers appear well-positioned to control the game. Given those factors, the run line becomes the more appealing option.
Los Angeles Dodgers vs San Francisco Giants Total Pick
Pick: Under 7.5
I’m leaning toward the under in this matchup because of the strong pitching numbers from Los Angeles and the overall lower run production from San Francisco. While the Dodgers have been scoring at a high rate, the Giants’ offense has been more limited, and the pitching from Los Angeles has been effective at keeping opponents in check. That combination points toward a game where the total could stay below the number.
Final Score Prediction: Los Angeles Dodgers 5 – San Francisco Giants 2
This prediction was written before the completion of game play on Tuesday.
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