Los Angeles Dodgers vs San Francisco Giants Picks, Prediction, Odds, and Line Movement for Friday September 25 2026
The Los Angeles Dodgers visit the San Francisco Giants on September 25, 2026 at 10:15 PM ET in an NL West matchup featuring one of the most lopsided pitching matchups on the board. This Dodgers vs Giants prediction centers on left-hander Tarik Skubal, who brings a 2.85 ERA, a 0.99 WHIP and 176 strikeouts into a start against right-hander Yunior Marte, who has worked just 19.1 innings this season. Los Angeles enters at 97-62, while San Francisco sits at 65-94, and both teams have dropped two straight. The Dodgers lead the season series 6-4 and have won the last three meetings. With the moneyline priced near -383, the run line is the practical way to back Los Angeles, and the Under has been heavily juiced at 7.5 throughout the market. Below you will find the odds, line movement, full matchup breakdown, injuries and our complete betting card. For more daily plays across the league, check out our MLB predictions.
Dodgers vs Giants TLDR: Quick Picks and Prediction
- Spread Pick: Dodgers -1.5 (-196)
- Total Pick: Under 7.5 (-124)
- Final Score Prediction: Dodgers 5, Giants 1
- Probable Starters: Tarik Skubal (LAD) vs Yunior Marte (SF)
Odds and Line Movement
Current Odds
| Team | Moneyline | Run Line | Total | Over | Under |
|---|---|---|---|---|---|
| Los Angeles Dodgers | -383 | -1.5 (-196) | 7.5 | +100 | -120 |
| San Francisco Giants | +296 | +1.5 | 7.5 | +100 | -120 |
Line Movement - Moneyline
| Date | LA Dodgers | San Francisco | Public ($, #) |
|---|---|---|---|
| 09/25 | -383 | +296 | LAD 96%, LAD 98% |
| 09/25 | -384 | +297 | LAD 95%, LAD 97% |
| 09/25 | -397 | +306 | LAD 95%, LAD 97% |
| 09/25 | -398 | +306 | LAD 95%, LAD 97% |
| 09/25 | -386 | +299 | LAD 95%, LAD 96% |
| 09/25 | -387 | +299 | LAD 95%, LAD 96% |
| 09/25 | -386 | +299 | LAD 95%, LAD 96% |
| 09/25 | -387 | +299 | LAD 95%, LAD 96% |
| 09/25 | -386 | +299 | LAD 95%, LAD 96% |
| 09/25 | -387 | +299 | LAD 95%, LAD 96% |
| 09/25 | -386 | +298 | LAD 95%, LAD 96% |
| 09/25 | -387 | +299 | LAD 95%, LAD 96% |
| 09/25 | -386 | +299 | LAD 95%, LAD 96% |
| 09/25 | -387 | +299 | LAD 95%, LAD 96% |
| 09/25 | -388 | +299 | LAD 100%, LAD 100% |
| 09/25 | -388 | +300 | LAD 100%, LAD 100% |
Line Movement - Total
| Date | Over | Under | Public ($, #) |
|---|---|---|---|
| 09/25 | 7.5 +100 | 7.5 -120 | OV 58%, OV 63% |
| 09/25 | 7.5 +103 | 7.5 -124 | OV 52%, OV 57% |
| 09/25 | 7 -123 | 7 +102 | OV 52%, OV 57% |
| 09/25 | 7.5 +103 | 7.5 -125 | OV 52%, OV 57% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -123 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -125 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +104 | 7.5 -125 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +102 | 7.5 -123 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -123 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -124 | UN 93%, UN 67% |
| 09/25 | 7.5 +103 | 7.5 -123 | UN 93%, UN 67% |
The Dodgers moneyline has been heavily priced all day. It sat around -388 early, climbed as high as -398 and has since settled back to -383, with the Giants moving between +296 and +306. Public support has been overwhelming, with Los Angeles drawing between 95 and 100 percent of both the money and the tickets. At prices this steep, the moneyline offers little return, which is why the run line is the preferred way to back the Dodgers.
The total has held at 7.5 for nearly the entire market, with the Under consistently juiced between -123 and -125. For most of the morning, the Under drew 93 percent of the money and 67 percent of the tickets. The number briefly dipped to 7 before returning to 7.5. The latest split has shifted to 58 percent of the money and 63 percent of the tickets on the Over, and that late action has trimmed the Under price to -120, the cheapest it has been all market.
Key Matchups and Game Preview: Dodgers at Giants
Los Angeles Looks to Snap a Two-Game Skid
Los Angeles enters at 97-62 but has dropped two straight games. San Francisco sits at 65-94 and has also lost two in a row. Neither team arrives with momentum, but the gap in overall quality is enormous. The Dodgers lead the season series 6-4 and have won the last three meetings by scores of 8-2, 10-4 and 3-1. With their ace on the mound, this is an ideal spot for the Dodgers to get back on track.
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Tarik Skubal Gives the Dodgers a Massive Edge
Skubal gives Los Angeles a massive starting pitching advantage. He enters 11-7 with a 2.85 ERA and a 0.99 WHIP across 151.2 innings. He has allowed just 123 hits and 27 walks while striking out 176, with only 14 home runs surrendered. A sub-1.00 WHIP means opponents barely reach base, and 27 walks in over 150 innings reflects elite command. Against a Giants lineup missing its top power bat, Skubal is well positioned to dominate from the first pitch.
Yunior Marte's Small Sample for the Giants
Marte has worked a much smaller sample for San Francisco. He is 0-1 with a 4.66 ERA and a 1.40 WHIP over 19.1 innings, allowing 18 hits, nine walks and three home runs with 11 strikeouts. That limited workload creates significant uncertainty against one of the deeper offenses in baseball. His walk rate and low strikeout total suggest the Dodgers should have plenty of opportunities to build scoring chances, and it is unlikely he works deep into this game.
Los Angeles Owns the Deeper Lineup
Los Angeles is batting .257 with a .339 OBP and a .425 slugging percentage while scoring 790 runs and hitting 199 home runs. That is a balanced, dangerous offensive profile. San Francisco is hitting .246 with a .308 OBP and a .403 slugging percentage, and those numbers were built with hitters who are no longer in the lineup. The Dodgers hold the edge in every major offensive category.
Freeman and Ohtani Power the Dodgers
Freddie Freeman leads Los Angeles with a .292 average and a .366 OBP, giving the Dodgers a consistent presence who can set up scoring chances. Shohei Ohtani has 30 home runs and 81 RBI while batting .278, providing the power in the middle of the order. With Marte's walk rate and limited track record, Freeman reaching base in front of Ohtani is a matchup that heavily favors Los Angeles.
Giants Offense Without Rafael Devers
San Francisco's lineup is considerably weaker with Rafael Devers on the injured list after leading the club with 37 home runs and 98 RBI. Replacing that power is a major challenge. Jung Hoo Lee remains one of the Giants' more reliable active bats at .276, but he cannot carry the offense alone. With Willy Adames also out and multiple players day-to-day, the Giants will struggle to generate runs against Skubal.
San Francisco's Pitching Gap
The Dodgers own a major team pitching edge with a 3.59 ERA and a 1.15 WHIP, compared with San Francisco's 4.36 ERA and 1.36 WHIP. Los Angeles has several pitchers sidelined, but its staff remains well ahead of the Giants. Once Marte exits, San Francisco's bullpen will need to hold down a deep Dodgers lineup, which is a difficult task for a staff with these numbers.
Betting Trends: LAD vs SF
- Los Angeles leads the season series 6-4.
- Los Angeles has won the last three meetings by scores of 8-2, 10-4 and 3-1.
- Both teams have lost two straight games.
- Los Angeles has scored 790 runs and hit 199 home runs this season.
- Los Angeles owns a 3.59 team ERA compared with San Francisco's 4.36.
- The Dodgers moneyline has ranged between -383 and -398.
- Los Angeles has drawn between 95 and 100 percent of the moneyline money and tickets.
- The Under has been priced between -120 and -125 at 7.5 for nearly the entire market.
Dodgers Recent Dominance in the Series
Los Angeles has won the last three meetings, and two of those wins came by six runs. The Giants allowed a combined 18 runs in the 8-2 and 10-4 losses, showing how well the Dodgers lineup has matched up against San Francisco's pitching. With Skubal on the mound and Devers out, the conditions for another comfortable Dodgers win are in place.
San Francisco Total Holds at 7.5
The Under has been priced as the favorite at 7.5 throughout the market, drawing 93 percent of the money for most of the day. The late Over action has trimmed the Under price to -120, which gives bettors a slightly better number. The market's steady support for the Under reflects the dominance of Skubal and the weakness of the Giants lineup.
Key Injuries and Things To Know: LAD vs SF
Dodgers Injury Report
- Gavin Stone: Sidelined.
- Jake Cousins: Sidelined.
- Ben Casparius: Sidelined.
- Brusdar Graterol: Sidelined.
- Dalton Rushing: On the IL.
Los Angeles is dealing with several pitching injuries, but with Skubal on the mound, the Dodgers are less dependent on their bullpen than usual. The team still owns a major pitching edge over San Francisco despite these absences.
Giants Injury Report
- Rafael Devers: On the injured list.
- Willy Adames: Out.
- Bo Davidson: Day-to-day.
- Osleivis Basabe: Day-to-day.
San Francisco's lineup has been gutted. Losing Devers removes the team's leader in home runs and RBI, and Adames' absence takes away another key bat. With Davidson and Basabe also day-to-day, the Giants' lineup depth is significantly reduced heading into a matchup against one of the best pitchers in the game.
Dodgers vs Giants Side and Over/Under Picks
Why the Dodgers Cover -1.5
With Skubal in dominant form, San Francisco missing Devers and Los Angeles holding major advantages in both offense and pitching, the Dodgers are positioned to control this matchup. Skubal's 0.99 WHIP and 176 strikeouts should overwhelm a depleted Giants lineup, while Freeman and Ohtani get to work against Marte's limited track record. At -383, the moneyline offers minimal value, while the run line at -196 provides a far better return on a team we project to win by four.
- Spread Pick: Dodgers -1.5 (-196)
Why Los Angeles and San Francisco Stay Under 7.5
Skubal is the driving force behind the Under. He has allowed just 123 hits and 27 walks in 151.2 innings, and he faces a Giants lineup missing Devers and Adames. San Francisco is unlikely to contribute more than a run or two, which means the Dodgers would need to score six or more for the Over to cash. The market has supported the Under at 7.5 all day, and we project six total runs.
- Total Pick: Under 7.5 (-124)
Los Angeles vs San Francisco Final Score Prediction
Expect Skubal to dominate from the start, racking up strikeouts against a Giants lineup without its most productive hitter. The Dodgers find their offense early against Marte, with Freeman and Ohtani driving the attack, and add on against San Francisco's bullpen. Los Angeles snaps its two-game skid with a comfortable win that covers the run line and stays under the total.
- Final Score Prediction: Dodgers 5, Giants 1
- Spread Pick: Dodgers -1.5 (-196)
- Total Pick: Under 7.5 (-124)
How to Wager On Dodgers vs Giants
At -383, the Dodgers moneyline is too expensive to bet on its own, so the run line at -196 is the recommended way to back Los Angeles. Bettors seeking more upside can consider an alternate run line on the Dodgers, since our projection has them winning by four, but the standard -1.5 offers the best balance of risk and reward. The moneyline has ranged as high as -398, so shop around for the cheapest run line price available.
On the total, the Under is currently priced at -120, which is cheaper than our -124 target after late Over action trimmed the juice. Lock it in while the price is favorable, and avoid the Under if the total drops to 7. Check the day-to-day status of Bo Davidson and Osleivis Basabe before first pitch, as their absence would further weaken the Giants lineup. Because both picks rely on Skubal controlling a depleted San Francisco offense, pairing Dodgers -1.5 with Under 7.5 fits the projected game script if your sportsbook offers fair correlated pricing. Keep stakes disciplined given the heavy juice on both positions.
For more data-driven tools to help you bet Dodgers vs Giants and the rest of the MLB slate, explore our guide to AI picks. You can also compare platforms through our Dimers review and our Oddible review to find the tools that best fit your betting approach.
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