Milwaukee Brewers vs Pittsburgh Pirates Picks and Prediction for Friday September 5 2025

By: Eddie Kline Published 09/05/2025, 12:40 AM ET

Brewers Preview

Scenic PNC Park will play host to a Friday night MLB clash between the Milwaukee Brewers and the Pittsburgh Pirates. Be ready for the baseball season with all of our MLB predictions. The Brewers (86-55) have split their previous ten games and hold a 5.5 game lead over Chicago for the top spot in the NL Central Division. On Thursday, Milwaukee batters went 0-for-10 with runners in scoring position and left eight men on base during a 2-0 home loss versus Philadelphia.

Twenty-four year old righty Quinn Priester (11-2 3.28 ERA) will take the mound for the Brewers in this matchup. The Brewers have won Priester’s previous 16 starts and he has allowed more than two runs just three times during that incredible stretch.

Pirates Preview

The Pittsburgh Pirates have won eight of their last 11 games and are trying to climb out of the NL Central Division cellar. Last night, NL Cy Young Award front runner Paul Skenes (10-9) fanned eight batters in six shutout innings to lead Pittsburgh to a 5-3 home victory versus Los Angeles. OF Bryan Reynolds went 2-for-3 and scored a pair of runs for the Pirates (64-77), who improved to 42-30 at home.

Pittsburgh interim manager Don Kelly has not announced a starting pitcher for the series opener. The Pirates currently rank tenth in the majors with a 3.88 ERA and have lagged 50 quality starts.

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Brewers vs Pirates Prediction

Milwaukee 1B Rhys Hoskins (thumb) is on a rehab assignment with Triple-A Nashville and should return to the lineup this weekend. Through 141 games, Milwaukee ranks 10th in OPS and 2nd in runs scored. For the season, Pittsburgh ranks 30th in OPS and 30th in runs scored. Take the Brewers to win on the road. Final Score Prediction, Milwaukee Brewers win 6-2.

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