Milwaukee Brewers vs San Diego Padres Picks and Prediction for Tuesday September 23 2025

By: Thomas Pemberton Published 09/23/2025, 12:30 AM ET
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The San Diego Padres remain at home for game two of their series against the Milwaukee Brewers. The Brewers have won the NL Central. While the Padres are currently three games behind the Dodgers in the NL West. San Diego will most likely see the playoffs of a wildcard team. Stay up to date with our expert's MLB Picks.

San Diego Padres Preview

The San Diego Padres are 2nd in the NL West with an 85-71 record. The Padres have won six of their last ten games and they carry a 47-28 home field record. San Diego entered this series riding a two-game win streak. The Padres are averaging 4.3 runs scored per game with 8.4 hits. San Diego is 9th best in the MLB with a .321 team on base percentage. Manny Machado leads the Padres on the season with 26 home runs. Randy Vasquez will make the start on the mound for the Padres. Vasquez is 5-7 on the season with 125.2 innings pitched. Vasquez has 74 strikeout and carries a 3.94 ERA. Vasquez pitched just 2.1 innings in his last outing allowing 4 earned runs on 4 hits.

Milwaukee Brewers Preview

The Milwaukee Brewers are the leaders of the NL Central with a 95-61 record. The Brewers have won six of their last ten games and they carry a 44-34 record. Milwaukee has the most wins in the MLB. The Brewers are averaging 5.1 runs scored per game and 8.9 hits per game. Milwaukee carries a .261 team batting average which is 2nd best in the MLB. Brice Turang leads the Brewers with 161 hits on the season. The Milwaukee Brewers carry a 3.62 team ERA which is 2nd best in the league. The Brewers have allowed 160 home runs on the season.

Brewers vs Padres Free Picks & Prediction:

The Milwaukee Brewers are hoping to remain the top NL team heading into the playoffs. The Brewers have lost two of their last four series. While the Padres are fighting to catch the Dodgers in the NL West. Watch for Randy Vasquez to struggle against this tough Brewers lineup.

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  • Final Score Prediction: Milwaukee Brewers win 6-5.

Brewers vs Padres Free Pick:

  • Milwaukee Brewers
  • OVER

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