Milwaukee Brewers Vs St Louis Cardinals Pick and Prediction for Friday, September 19, 2025

By: Ricky Mackenzie Published 09/19/2025, 01:00 AM ET

Brewers Preview

Jacob Misiorowski and the Milwaukee Brewers will head to Busch Stadium to face Sonny Gray and the St. Louis Cardinals on Friday night. Get our free MLB Picks all season long! Milwaukee enters with the NL Central lead and a 93-59 record, while St. Louis continues to play out a disappointing season at 74-79, sitting fourth in the division.

Misiorowski has been a steady piece in Milwaukee’s rotation, owning a 5-2 record and 4.35 ERA through 60 innings. The young right-hander features a strong fastball and wipeout slider, with 81 strikeouts already logged. He’ll need to avoid deep counts and limit free passes to keep the pressure off the bullpen.

Cardinals Preview

Gray counters with more experience, holding a 13-8 mark across 168.2 innings with a 4.43 ERA. He’s capable of navigating tough lineups when his command is sharp, but lately he’s struggled with elevated pitch counts and hard contact. Milwaukee’s patient hitters could force him into trouble early if they stay disciplined.

The Brewers have more to play for, and they’ve looked like a focused, postseason-ready club. Their bullpen is among the most reliable in baseball, and their defense rarely gives away extra outs. St. Louis will need a near-perfect night from Gray and timely hitting to keep things close into the late innings.

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Brewers vs Cardinals Pick

Milwaukee’s playoff urgency and well-rounded execution give them the upper hand in this one. Unless Gray recaptures early-season form, the visitors should have enough offense and pitching depth to get it done. Take the Brewers to grab the win on the road. Final Score Prediction, Milwaukee Brewers win 6-3.

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