Milwaukee Brewers vs St. Louis Cardinals Picks and Prediction for Sunday, September 21, 2025
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The Milwaukee Brewers (95-60) make the trip to Busch Stadium to take on the St. Louis Cardinals (75-80) in the final game of their three-game weekend series. First pitch is scheduled for 2:15 PM ET. Freddy Peralta (17-6, 2.65 ERA) is projected to start for Milwaukee, while the Cardinals counter with Matthew Liberatore (7-12, 4.30 ERA). Get in on the action with our free MLB picks.
Brewers Analysis
Milwaukee has been dominant this season, especially in the NL Central. Peralta has been one of their most reliable starters: in his 17 wins, he’s posted a 2.65 ERA and a WHIP near league-top among qualified starters. The Brewers’ offense remains deep: William Contreras is solid (.264 AVG with 17 HR, 82 walks), Brice Turang is driving in runs, and Christian Yelich continues to contribute with solid extra-base power. With playoff positioning on the line, Milwaukee is likely to lean heavily on both Peralta’s start and bullpen depth.
Cardinals Analysis
St. Louis enters this game well out of playoff contention, currently below .500 and heading toward a rebuilding offseason. Liberatore has struggled more than he has succeeded in 2025: a 7-12 record, 4.30 ERA, 116 strikeouts, 1.31 WHIP. The Cardinals’ offense has had flashes, with Nolan Arenado and Alec Burleson providing power and some consistency, but the overall lineup has underperformed — OPS in the .690-.700 range, not enough to overcome pitching deficits. Liberatore’s recent outings have been hit-or-miss, making the home team vulnerable if Milwaukee jumps early.
Standout Players and Key Injuries
- Brewers:• Freddy Peralta – possibly Milwaukee’s best starter this season, low ERA, good era over recent starts. • William Contreras and Brice Turang with hot streaks at the plate; lineup depth gives Milwaukee flexibility.
- Cardinals:• Matthew Liberatore – struggles with consistency; offers strong change-ups but often hurt by hard contact. • Nolan Arenado and Alec Burleson – the primary offensive weapons; their production will need to be clutch for any shot.
Prediction Reasoning
This matchup heavily favors the Brewers. With Peralta pitching well, a deeper lineup, and stronger recent form, Milwaukee is in control. The Cardinals may keep it somewhat close early, but unless Liberatore is his absolute best, Milwaukee should pull away in the middle innings. Expect the Brewers to take the series finale on the road.
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Final Score Projection: Brewers 6, Cardinals 3
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Brewers vs Cardinals Best Picks
- Brewers ML
- UNDER 9 runs
