Milwaukee Brewers vs. St. Louis Cardinals Picks and Predictions for Saturday September 20, 2025

By: Dylan Hellebrand Published 09/20/2025, 12:30 AM ET
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On Saturday, the Milwaukee Brewers (93-59) face off against the St. Louis Cardinals (74-79) at Busch Stadium in St. Louis, Missouri. The game will be aired on FanDuel Sports Network Wisconsin and FanDuel Sports Network Midwest. Keep up to date with all the MLB action, with our MLB picks.

Game Information For Brewers vs Cardinals

  • September 20, 2025, 7:15pm EST
  • Busch Stadium
  • FanDuel Sports Network Wisconsin/FanDuel Sports Network Midwest
  • 83° cloudy/rain at start time

St. Louis Cardinals Form & Recent Results

St. Louis enters this series against Milwaukee coming off a loss, having fallen in three of their previous five contests. Most recently, the Cardinals suffered a 6-2 defeat to the Cincinnati Reds on Wednesday. In that game, Alec Burleson stood out by driving in a run and going 2-for-3 at the plate, including a solo home run. On the season, catcher Willson Contreras has been the Cardinals’ main power threat, topping the team with 20 home runs. Burleson is right behind him, having hit 18 homers himself to rank second on the club. Contreras also leads the Cardinals in runs batted in, collecting 80 RBIs so far this year. Burleson has been the team’s most consistent hitter by average, carrying a .285 mark into this matchup. Defensively, St. Louis has struggled of late, allowing an average of 5.6 runs per game over their past five games, a stretch that has just about eliminated them from postseason contention. With their playoff hopes all but dashed, the Cardinals are now simply looking to string together some wins as the season winds down. For the year as a whole, the team is averaging 4.3 runs per game on offense.

Milwaukee Brewers Form & Recent Results

The Milwaukee Brewers come into this matchup riding a two-game winning streak and have taken victory in four of their last five contests, setting up their final game against the Angels and their upcoming series opener versus St. Louis with strong momentum. The Brewers cruised to a 9-2 win over the Angels on Wednesday. In that game, Sal Frelick contributed significantly, going 1-for-3 at the plate with a home run, tallying three RBIs, and scoring a run. Throughout the season, Christian Yelich has been Milwaukee’s biggest power hitter, leading the team with 29 home runs. Right behind him is Jackson Chourio, who has hit 20 homers, making him the team’s second-leading long-ball threat. Yelich is also tops for the Brewers when it comes to runs batted in, accumulating 99 RBIs so far this year, another testament to his pivotal role in Milwaukee’s lineup. When it comes to batting average, Sal Frelick sets the pace for the team, hitting an impressive .296 for the season. Milwaukee’s offense has been particularly explosive over their last five games, putting up an average of 7.4 runs as their bats have heated up at just the right time. This late-season surge is promising as the Brewers gear up for a playoff run. Overall, they are averaging 5.1 runs per game, demonstrating consistent production at the plate throughout the season.

Starting Pitchers For Brewers and Cardinals 

  • Milwaukee’s Chad Patrick against St. Louis this year: 0-1, 3.38 ERA, 3 K
  • St. Louis’ Miles Mikolas against Milwaukee this year: 1-1, 3.27 ERA, 12 K

Brewers vs Cardinals Picks and Prediction

The Brewers have been one of the hottest teams in baseball lately, consistently stringing together wins as they gear up for a postseason run. With the playoffs just around the corner, the Brewers are aiming to maintain their strong momentum and finish the regular season on a high note. Their next challenge is a series against the Cardinals, a team they've already had considerable success against this year. Milwaukee has taken six out of their ten matchups versus St. Louis, and they’ll be hoping to build on that track record in the upcoming games. On the mound for the Brewers will be Chad Patrick, who has a 3-8 record, with a respectable 3.64 ERA. Opposing him for the Cardinals is Miles Mikolas, who has posted an 8-10 record and a 4.80 ERA so far this season. Final Score Prediction, Milwaukee Brewers win 3-2.

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