Minnesota Twins vs Chicago White Sox Picks and Prediction for Saturday, September 5, 2026
The Minnesota Twins visit the Chicago White Sox on Saturday at 7:10 p.m. ET at Rate Field in Chicago, with 77-degree weather expected. Minnesota is 67-73, third in the AL Central and six games behind Chicago, while the White Sox lead the division at 73-67. The Twins are 29-39 on the road and have lost their most recent game 11-6 to Detroit in 12 innings. Chicago is 41-27 at home but enters on a two-game losing streak after a 6-2 loss at Houston. The White Sox lead the season series 6-4. Taj Bradley starts on the mound for Minnesota, while Anthony Kay will start for Chicago. Cash in a winner with our free MLB picks.
Minnesota Twins
Bradley enters 10-6 with a 3.85 ERA and 1.26 WHIP across 154.1 innings. The right-hander has struck out 178 batters while allowing 129 hits, 66 walks and 21 home runs. Those numbers give Minnesota the stronger starting pitching profile in this matchup. The Twins' overall staff has been less reliable, ranking 25th in MLB with a 4.63 ERA and carrying a 1.38 WHIP.
Minnesota is batting .246 with a .320 on-base percentage and .409 slugging percentage. Luke Keaschall leads the regular lineup with a .278 average and .369 OBP, while Josh Bell has 83 RBI. Byron Buxton leads Minnesota with 25 home runs but is on the 10-day injured list with an estimated September 6 return. The Twins have still produced plenty of offense recently, scoring 37 runs over their last three games against Detroit.
Chicago White Sox
Kay brings a 9-7 record, 4.28 ERA and 1.35 WHIP into Saturday. The left-hander has allowed 136 hits in 136.2 innings with 113 strikeouts, 49 walks and 19 home runs. Chicago's pitching staff has stronger season numbers than Minnesota's, posting a 4.13 ERA and 1.31 WHIP while holding opponents to a .240 batting average. That staff ranks 14th in MLB in ERA.
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The White Sox are hitting .237 with a .319 OBP and .406 slugging percentage, but Chicago has more home-run power with 181 compared with Minnesota's 165. Miguel Vargas has 29 home runs, 76 RBI and an .848 OPS, while Colson Montgomery also has 29 homers with a team-high 79 RBI. Chase Meidroth leads Chicago with a .273 average. Recent production is the concern: the White Sox have scored only 11 runs across their last five games while going 1-4.
Minnesota Twins vs Chicago White Sox Prediction
Taj Bradley provides Minnesota with the better starting pitcher, and the Twins arrive with the hotter lineup. Minnesota has scored at least five runs in four straight games, including 15 and 11 in consecutive wins over Detroit. Chicago has been held to two runs or fewer in three of its last five games. The White Sox have the better record, stronger home mark and better overall pitching numbers, but Bradley's strikeout production can limit a Chicago lineup batting .237. Minnesota has also won three of its last four games. The Twins have the advantage in Saturday's pitching matchup and will take a close game on the road. Final Score Prediction: Minnesota Twins win, 4-3.
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