Minnesota Twins vs New York Mets Picks and Predictions for Wednesday April 22 2026
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The Minnesota Twins and New York Mets are set to meet at Citi Field in Queens, New York on Wednesday, April 22, 2026, with first pitch scheduled for 7:10 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. Make sure to check out free MLB picks.
Starting Pitchers Taking the Ball
The Minnesota starter for this matchup is currently listed as undecided, with no statistics available. On the other side, Clay Holmes will take the mound for New York, entering with a 2-2 record, a 1.96 ERA, and a 1.09 WHIP over 23.0 innings. He has allowed 16 hits, struck out 16, walked 9, and given up 2 home runs. 
Twins Searching for Answers After Tough Stretch
Minnesota comes into this matchup with an even 11-11 record and a 4-5 mark on the road. The Twins have struggled recently, having recently lost to Cincinnati in multiple games, including 7-4 in extra innings, 5-4, and 2-1. They also recently lost to Boston 9-5 before picking up a 6-0 win in that same stretch. The recent results highlight a team that has had difficulty finding consistency over its last five games.
From a statistical standpoint, Minnesota is hitting .230 with 112 runs, 166 hits, and 26 home runs. The Twins have posted a .332 on-base percentage and a .381 slugging percentage. On the pitching side, they carry a 4.06 ERA and a 1.37 WHIP, while allowing opponents to hit .253. The staff has recorded 183 strikeouts and issued 78 walks.
One key concern for Minnesota has been its pitching consistency. While the ERA sits at 4.06, the WHIP of 1.37 and opponent batting average of .253 suggest that opposing offenses have been able to generate opportunities, especially during their recent losing stretch.
Mets Hoping to Snap Skid at Home
New York enters this game with a 7-15 record and a 3-6 mark at home. The Mets have struggled significantly in recent games, recently losing to Chicago multiple times, including 2-1 in extra innings, 4-2, and 12-4. They also recently lost to Los Angeles by scores of 8-2 and 2-1. That stretch has made it difficult for the team to build momentum.
Offensively, New York is hitting .226 with 72 runs, 169 hits, and 16 home runs. The Mets have posted a .288 on-base percentage and a .336 slugging percentage. On the pitching side, they hold a 4.06 ERA and a 1.28 WHIP, while allowing opponents to hit .239. The staff has recorded 190 strikeouts and issued 75 walks.
A key weakness for New York has been its offensive production. The lower run total and slugging percentage compared to Minnesota indicate that the Mets have struggled to consistently generate scoring, which has contributed to their recent losing stretch.
Minnesota Twins vs New York Mets Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bruce Marshall | +6,749.00 |
| 2 |  Bryan Power | +5,537.00 |
| 3 |  Tony Karpinski | +4,340.00 |
| 4 |  Pro Sports Picks | +3,905.00 |
| 5 |  The Gold Sheet | +2,237.00 |
Minnesota Twins vs New York Mets Pick
Pick: Minnesota Twins Moneyline
Minnesota holds a slight edge in offensive production, particularly with more runs scored and a higher slugging percentage compared to New York. While both teams have similar pitching ERAs, the Twins’ ability to generate more offense gives them an advantage in a matchup where scoring could be limited. With New York struggling to produce runs consistently, Minnesota appears to have the better path to securing a win.
Minnesota Twins vs New York Mets Total Pick
Pick: Take the under if the total is set at 8
I would lean toward the under in this matchup based on both teams’ offensive challenges and comparable pitching numbers. New York has struggled to score, while Minnesota has also had difficulty maintaining consistency at the plate in recent games. With both teams carrying similar ERAs and neither offense standing out as dominant, this game sets up as one where runs could be limited.
Final Score Prediction: Minnesota Twins 4 – New York Mets 3
This prediction was written before the completion of game play on Wednesday.
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