Minnesota Twins vs Philadelphia Phillies Picks and Prediction for Friday September 26 2025

By: Eddie Kline Published 09/26/2025, 12:50 AM ET

Twins Preview

Citizens Bank Park will play host to a Friday night MLB interleague clash between the Minnesota Twins and the Philadelphia Phillies. Be ready for the baseball season with all of our MLB predictions. The Twins (69-90) pressed the reset button at the MLB trade deadline and are 16 games below .500 on the road. On Thursday, OF Byron Buxton crushed two long balls and drove in four runs to power Minnesota to a 4-0 road victory against Texas.

Twenty-nine year old righty Joe Ryan (13-9 3.47 ERA) will take the mound for the Twins in this matchup. Last time out, Ryan (5 IP) was tagged for six hits and five runs (4 ER) during a 6-0 home loss versus Cleveland.

Phillies Preview

The Philadelphia Phillies have clinched their second consecutive NL East Division title and trail Milwaukee by two games for the top seed in the National League playoffs. Last night, Philadelphia 3B Alec Bohm went 2-for-4 with an RBI during a 1-0 home victory versus Miami. SP Walker Buehler (10-7) allowed three hits across five shutout frames to earn the win for the Phillies (94-65), who improved to 53-25 at home.

Philadelphia skipper Rob Thomson will turn to struggling righty Aaron Nola (4-10 6.46 ERA) on Friday. In his last start, Nola (5.1 IP) gave up seven hits and four runs during a 4-3 road loss against Arizona.

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Twins vs Phillies Pick

Philadelphia SS Trea Turner (hamstring) is expected to be activated from the 10-day injured list for this series. Through 159 games, Minnesota ranks 17th in OPS and 21st in runs scored. For the season, Philadelphia ranks 3rd in OPS and 6th in runs scored. Take the Twins to win on the road. Final Score Prediction, Minnesota Twins win 5-4.

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