New York Mets vs Philadelphia Phillies Picks and Predictions for Wednesday, September 10, 2025

By: David Anicetti Published 09/10/2025, 12:15 AM ET
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Mets vs Phillies Preview

Citizens Bank Park hosts a key NL East matchup when the New York Mets visit the Philadelphia Phillies on Wednesday at 6:45 PM ET. The Mets are looking to halt a slide, and the Phillies are trying to extend their lead at the top of the division. New York has dropped four of five, including a 1-0 loss here on Monday, while Philadelphia has won four of its last five. The mound duel features New York’s Clay Holmes (11-7, 3.61 ERA, 1.33 WHIP) against lefty Philly’s Cristopher Sánchez (12-5, 2.60 ERA, 1.12 WHIP). Be ready for all the baseball action with our free MLB Picks.

New York Mets Preview

New York’s success revolves around power from Juan Soto and Pete Alonso and timely hitting from Francisco Lindor. The Mets own a .250/.329/.429 team slash line with 197 homers, and Soto’s 38 home runs lead the way. Alonso leads the club with 113 RBI and a .518 slugging percentage, and Lindor’s 153 hits top the team, but run production has cooled during New York’s current 1-4 stretch.

Clay Holmes has 117 strikeouts in 147.0 innings, but 59 walks could extend frames for a Phillies club that takes advantage of pitchers’ mistakes. Health also matters: outfield depth has been thinned at times all season, and New York’s recent one-run losses display how the margin of error for the club is small and why they need excellent pitching on Wednesday from Holmes.

Philadelphia Phillies Preview

Philadelphia has a solid team slash line at .258/.328/.425 and an excellent 46-23 home record. Kyle Schwarber is doing the power hitting with 49 homers and 120 RBI, while Trea Turner’s .305 average and 179 hits keep innings alive. However, Turner was just placed on the 10-day IL. The Phillies have overcome nagging injuries all season, and Turner’s absence should not affect the outcome of this game.

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Christopher Sánchez has been a difference maker this season for Philly. The lefty’s 186 strikeouts against just 42 walks in 176.1 innings and his 1.12 WHIP play perfectly against a Mets lineup that has used the long ball all season to score. If Sanchez gets ahead in the count early, Philly should hand the ball over to the bullpen with a comfortable lead late.

New York Mets vs Philadelphia Phillies Prediction

Philadelphia has performed better of late as the Phillies are 4-1 in the last five, and New York is 1-4 in the last five. Sánchez’s strike-throwing plus a deeper overall lineup give Philadelphia the advantage, as does playing at home. Final Score Prediction: Philadelphia Phillies win 7-2.

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