New York Yankees vs Boston Red Sox Picks and Predictions for Friday, September 12, 2025

By: David Anicetti Published 09/12/2025, 12:10 AM ET

Yankees vs Red Sox Game Preview

The New York Yankees open a three-game series on the road Friday versus the Boston Red Sox at Fenway Park with the first pitch scheduled for 7:10 PM ET. New York enters at 80-65 (37-34 away) and just dropped two lopsided games to Detroit after a tough series win over Toronto. Boston is 81-66 overall and 44-28 at home. Probable starters are right-handers Luis Gil (3-1, 3.31 ERA, 1.53 WHIP in 35.1 innings pitched) for the Yankees and Lucas Giolito (10-3, 3.38 ERA, 1.26 WHIP in 130.1 innings pitched) for the Red Sox. Get all the baseball action with our free MLB Picks.

New York Yankees Preview

New York’s offense is tough to face due to its power in the middle of the order. The Yankees have produced 752 runs with a .248/.328/.453 team line and 246 homers. Aaron Judge continues to produce high numbers at the plate with a line of .319/.440/.656 with 44 homers and 98 RBI, and Cody Bellinger has chipped in well (.277, 28 HR, .835 OPS).

The Yankees have struggled on the mound of late as the bullpen fell apart in two consecutive games earlier this week. However, overall, New York has a 4.02 team ERA. Gil’s numbers in limited action are not the best, with 30 strikeouts and 23 walks in 35.1 innings. If Gil cannot locate his fastball well against Boston’s patient lineup, the Yankees could be in for another long game on the mound and need a suspect bullpen early..

Boston Red Sox Preview

Boston brings steadier pitching and an offense that can score in different ways. The Red Sox own a 3.74 team ERA and 1.29 WHIP, while having a team slash line of .254/.324/.425 resulting in 726 runs. Trevor Story leads with 24 homers and 91 RBI, while Jarren Duran has a team high 146 hits and gets on base at a .334 clip. Alex Bregman has a .362 on-base percentage, and Wilyer Abreu leads in slugging percentage.

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Giolito has performed well across 130.1 innings with 107 strikeouts, and his 1.26 WHIP is solid in a park where limiting base runners matters. The Boston bullpen has performed better over the last few weeks than New York’s, and if Giolito can reach the sixth and even better the seventh inning, the Red Sox have a much better opportunity.

New York Yankees vs Boston Red Sox Prediction

Boston playing at home and having a starting pitcher in better form favors the Red Sox on Friday against the Yankees. Giolito should be able to neutralize some of New York’s power at the plate, while Yankees starter Gil has had control issues, which could result in multiple baserunners for Boston, as the Red Sox lineup is very patient at the plate. With Boston 44-28 at home and New York coming off back-to-back blowout losses, take the Red Sox. Final Score Prediction: Boston Red Sox win 6-3.

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