New York Yankees vs Houston Astros Picks and Predictions for Saturday April 25 2026

By: Kim Smith Published 04/25/2026, 01:15 AM ET
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The New York Yankees travel to face the Houston Astros at Daikin Park in Houston, Texas on Saturday, April 25, 2026, with first pitch scheduled for 7:10 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. This matchup features two teams trending in opposite directions, with New York riding strong momentum and Houston looking to find consistency. For additional insights across the league, check out free MLB picks.

Starting Pitchers Preview

New York is set to start Ryan Weathers, while Houston will counter with Mike Burrows. Weathers enters this game with a 1-2 record, carrying a 3.18 ERA and a 1.24 WHIP across 28.1 innings. He has allowed 27 hits while striking out 36 batters and issuing eight walks, along with surrendering four home runs. On the other side, Burrows comes in with a 1-3 record and a 6.75 ERA, along with a 1.69 WHIP over 26.2 innings. He has allowed 36 hits, struck out 25, walked nine, and given up five home runs, reflecting challenges in limiting baserunners and run production.

Yankees Riding Momentum on the Road

New York enters this contest with a 16-9 overall record and an 8-4 mark away from home. Their recent stretch has been dominant, as they recently won over Boston in three consecutive games and also recently defeated Kansas City in convincing fashion. This run of success highlights a team that has found a strong rhythm on both sides of the ball.

From a statistical standpoint, the Yankees are hitting .223 with 122 runs and 181 hits, along with 35 home runs. Their .322 on-base percentage and .408 slugging percentage show a lineup that relies heavily on power to generate offense. On the pitching side, they hold a 3.07 ERA with a 1.11 WHIP, allowing opponents to hit just .219 while striking out 219 batters and issuing only 66 walks.

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The biggest strength for New York is its pitching efficiency. With a low ERA and WHIP, combined with strong strikeout numbers and limited walks, the Yankees have consistently controlled games and limited opposing scoring opportunities.

Houston Searching for Consistency at Home

Houston comes into this matchup with a 10-16 overall record and a 7-6 mark at home. Their recent stretch has been mixed, as they recently won over Cleveland twice but also recently lost to Cleveland and St. Louis in close games. This inconsistency has made it difficult for them to build sustained momentum.

Statistically, the Astros are hitting .259 with 137 runs and 229 hits, along with 31 home runs. Their .349 on-base percentage and .434 slugging percentage indicate a lineup that can generate offense at a high level. However, their pitching has struggled, as they carry a 5.81 ERA with a 1.63 WHIP, allowing opponents to hit .262 while striking out 245 batters and issuing 141 walks.

The primary concern for Houston is its pitching. With one of the higher ERAs and WHIPs in this matchup, along with a large number of walks, they have allowed opposing teams to create frequent scoring opportunities.

Yankees vs Astros Picks and Prediction

Yankees vs Astros Pick

Pick: Yankees Moneyline

New York holds a clear advantage in this matchup due to its superior pitching metrics and recent form. With a significantly lower team ERA and WHIP, the Yankees have been far more effective at limiting baserunners and preventing runs. Meanwhile, Houstonโ€™s pitching struggles, particularly with a high ERA and walk total, suggest they may have difficulty containing a power-driven lineup. With strong road performance and consistent results, New York is positioned to control this game.

Yankees vs Astros Total Pick

Pick: Over 9.5

Iโ€™m leaning toward the over in this matchup because Houstonโ€™s pitching numbers suggest that runs could be available for New York. At the same time, Houstonโ€™s offense has been productive with a high batting average and slugging percentage, which could allow them to contribute as well. With both teams capable of scoring and Houstonโ€™s pitching allowing opportunities, this game has the potential to exceed the total.

Final Score Prediction: New York Yankees 7 โ€“ Houston Astros 4

This prediction was written before the completion of game play on Friday.

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