New York Yankees vs Minnesota Twins Picks, Prediction, Odds, and Line Movement for Wednesday September 16 2026

By: Kyle Kargel Published 09/16/2026, 08:00 AM ET
Yankees vs Twins prediction

New York looks to complete a series sweep Wednesday afternoon in one of the more lopsided pitching matchups on today's MLB predictions slate, as the Yankees travel to Target Field to close out a three-game set against the Minnesota Twins. New York enters at 88-63 after taking the first two games by scores of 8-3 and 8-1, while Minnesota sits at 70-81 and has dropped four of its last five. With Carlos Rodon on the mound for New York against Zebby Matthews for Minnesota, this Yankees vs Twins finale offers plenty of angles for bettors looking to close out the day strong.

TLDR: Quick Picks and Prediction

  • Spread Pick: New York Yankees -1.5 (+114)
  • Total Pick: Under 8 (-112)
  • Final Score Prediction: Yankees 5, Twins 2

Odds and Line Movement

Current Odds

Team Spread Moneyline Total
New York Yankees -1.5 (+114) -148 8
Minnesota Twins +1.5 (-137) +123 8

Line Movement - Moneyline

Date NY Yankees Minnesota Public
09/16 -148 +123 NYY 97%, NYY 86%
09/16 -147 +122 NYY 97%, NYY 86%
09/16 -147 +121 NYY 97%, NYY 86%
09/16 -147 +122 NYY 96%, NYY 84%
09/16 -143 +119 NYY 96%, NYY 83%
09/15 -144 +119 NYY 79%, NYY 75%
09/15 -149 +123 -

Line Movement - Total

Date Over Under Public
09/16 8-108 8-112 OV 96%, OV 67%
09/16 8-109 8-110 OV 100%, OV 100%
09/16 8-109 8-111 OV 100%, OV 100%
09/16 8-109 8-110 -
09/15 8-111 8-109 -
09/15 8-110 8-109 -
09/15 8-111 8-109 -
09/15 8-110 8-109 -
09/15 8-111 8-109 -
09/15 8-110 8-109 -

Yankees vs Twins Key Matchups and Game Preview

Rodon Brings a Major Edge to the Mound

Carlos Rodon has been outstanding for New York this season, sitting at 6-3 with a 2.94 ERA and 1.12 WHIP across 70.1 innings. He has allowed just 44 hits and six home runs while striking out 78 against only 35 walks, and his recent form has been even sharper, entering this start with a 2.25 ERA over his previous five outings. That level of run prevention and consistency gives New York a significant advantage in this finale.

Matthews Struggles With the Long Ball

Zebby Matthews takes the mound for Minnesota with a 9-10 record, 4.98 ERA and 1.27 WHIP through 119.1 innings. He has allowed 115 hits and 23 home runs while striking out 99 and walking 37, making him considerably more hittable than his counterpart and a pitcher New York's power-heavy lineup should be able to attack.

Yankees Power and Depth Stand Out

New York has hit 209 home runs on the season with a .411 slugging percentage, both ahead of Minnesota's 175 homers and .404 slugging mark. Ben Rice has emerged as a major offensive force with 38 home runs and 92 RBI while batting .262, and Cody Bellinger leads the Yankees with a .272 average. Rice also brings a strong personal history against Matthews, going 4-for-8 with a double and a homer in his career versus the Twins right-hander.

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Twins Missing Their Top Offensive Threat

Minnesota's Luke Keaschall leads the team with a .276 average, Kody Clemens has contributed 26 home runs, and Josh Bell has driven in 87 runs. Still, the Twins remain without Byron Buxton, who is on the injured list, taking away one of their most dangerous all-around threats at the top of the lineup.

New York's Pitching Staff Dominates the Numbers

Beyond Rodon, New York holds a wide overall pitching advantage with a 3.21 team ERA and 1.16 WHIP compared to Minnesota's 4.70 ERA and 1.38 WHIP. That gap in run prevention across the staff is one of the clearest indicators in this matchup and a major reason the Yankees are positioned as heavy favorites.

Yankees Dealing With Their Own Absences

New York is not fully healthy either, with Trent Grisham and Giancarlo Stanton both out, while pitchers Clarke Schmidt, Ryan Weathers and Fernando Cruz are also sidelined. Even with those absences, the Yankees' remaining lineup and rotation depth have been more than enough to carry this series so far.

Yankees Riding Momentum Into the Finale

New York has won four of its last five games overall and has outscored Minnesota by a combined 16-4 margin through the first two games of this series. That kind of momentum, paired with Rodon's recent form, sets up well for a Yankees team looking to complete the sweep on the road.

Twins Look to Avoid the Sweep at Home

Minnesota has lost four of its last five games and will need a strong outing from Matthews just to keep this game competitive. With Buxton unavailable and the Twins already facing a difficult pitching matchup, avoiding the sweep will require a much sharper performance than they have shown across the first two games of the series.

The run line and moneyline have shown steady Yankees support throughout the pregame window, with New York's number moving from -143 up to as strong as -149 before settling at -148, while Minnesota's price has ranged between +119 and +123. Public betting has been overwhelmingly on New York, with reported splits showing the Yankees drawing between 75% and 97% of tickets and dollars across the available line-movement snapshots.

The total has held mostly steady around 8 runs, with movement between -108 and -112 on the under and -108 to -111 on the over. The most recent snapshots show over money as high as 100% of tickets and dollars in some updates, though the closing numbers reflect a total that has stayed firmly anchored at 8.

Key Injuries and Things To Know for NYY and MIN

  • New York Yankees: OF Trent Grisham (out), OF Giancarlo Stanton (out), RHP Clarke Schmidt (out), LHP Ryan Weathers (out), RHP Fernando Cruz (out)
  • Minnesota Twins: OF Byron Buxton (injured list)
  • New York (88-63) has won the first two games of the series 8-3 and 8-1 and has won four of its last five overall
  • Starting pitchers: Carlos Rodon (6-3, 2.94 ERA) for New York vs. Zebby Matthews (9-10, 4.98 ERA) for Minnesota

Yankees vs Twins Side and Over/Under Picks

  • Side Pick: New York Yankees -1.5 (+114)
  • Total Pick: Under 8 (-112)
  • Reasoning: Rodon's ability to limit hits and home runs, combined with Matthews' home-run vulnerability and New York's superior lineup depth, makes the run line more attractive value than laying the moneyline price.

Final Score Prediction

  • New York Yankees: 5
  • Minnesota Twins: 2

With Rodon locating well in his recent starts and Matthews carrying a clear home-run problem, New York's power and pitching combination should be enough to cover the run line comfortably while keeping this game under the total in a series-sweeping effort.

How to Wager On Yankees vs Twins

Bettors building out a full card around this Yankees vs Twins finale have a few additional resources worth exploring. For a broader look at model-driven picks across today's slate, check out these AI picks. Those wanting a deeper dive into specific modeling tools can also read the Dimers review or the Oddible review for additional perspective on how projection-based systems view this matchup and other games on the board.

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