Padres vs Pirates Picks and Predictions for Monday April 6 2025

By: Jeremy O'Quinn Published 04/06/2026, 12:50 AM ET

Padres Preview

The San Diego Padres will travel to PNC Park on Monday, where they’ll open a series against the Pittsburgh Pirates. Get the rest of our free MLB picks here! San Diego comes into this matchup trying to build momentum after a series win, while Pittsburgh has been one of the early surprises of the 2026 season. The Padres have had a slow but improving start to the year, sitting at 4-5 through their first nine games. Offensively, San Diego is averaging 5.6 hits and 2.7 runs per game so far this season, numbers that rank near the bottom of MLB early on. San Diego is expected to send Germán Márquez to the mound on Monday. Márquez has struggled early in 2026, posting a 12.00 ERA in his first outing.

Pirates Preview

The Pirates come into this matchup with strong early-season form, sitting at 6-3 and riding a five-game winning streak.   Pittsburgh has been one of the more productive offensive teams early, averaging 9.1 hits and 5.3 runs per game, showing a balanced attack that has overwhelmed opponents in recent games. The Pirates are projected to counter with Bubba Chandler on the mound. Chandler has been impressive in his first appearance of the 2026 season, posting a 0.00 ERA with 6 strikeouts. The young right-hander is still establishing himself at the major league level.

Pirates vs Padres Pick

Pittsburgh is seeking their sixth straight win on Monday, while San Diego comes into winning consecutive games themselves. Expect the momentum to continue in Pittsburgh, as they cover the -1.5 spread en route to the win. Final score prediction, Pirates win 5-3.

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