Philadelphia Phillies vs Chicago Cubs Picks and Predictions for Wednesday April 22 2026
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The Philadelphia Phillies and Chicago Cubs are set to meet at Wrigley Field in Chicago, Illinois on Wednesday, April 22, 2026, with first pitch scheduled for 7:40 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. Make sure to check out our free MLB picks.
Starting Pitchers Overview
The Philadelphia starter for this matchup is currently listed as undecided with no statistics provided. On the other side, Matthew Boyd is scheduled to take the mound for Chicago, entering with a 1-1 record, a 6.75 ERA, and a 1.18 WHIP over 9.1 innings. He has allowed 8 hits while striking out 17 and walking 3, with 1 home run surrendered. 
Phillies Trying to Break Out of Recent Slide
Philadelphia enters this contest with an 8-14 record and a 3-4 mark on the road. The Phillies have struggled significantly over their last five games, recently losing to Chicago 5-1 and also dropping multiple games against Atlanta by scores of 4-2, 3-1, and 9-0. They also recently lost to Chicago 11-2 in that stretch. That sequence highlights a team that has had difficulty finding any sustained success in recent outings.
From a statistical standpoint, Philadelphia is hitting .220 with 76 runs, 162 hits, and 22 home runs. The Phillies have posted a .301 on-base percentage and a .360 slugging percentage. On the pitching side, they carry a 4.87 ERA and a 1.42 WHIP, while allowing opponents to hit .275. The staff has recorded 219 strikeouts and issued 64 walks.
A clear concern for Philadelphia has been its pitching performance. The 4.87 ERA and .275 opponent batting average indicate that opposing teams have consistently been able to generate offense, which has made it difficult for the Phillies to stay competitive during this recent stretch.
Cubs Carrying Confidence at Home
Chicago comes into this matchup with a 13-9 record and an 8-5 mark at home. The Cubs have been in strong form recently, recently winning over Philadelphia 5-1 and also picking up victories against New York in multiple games by scores of 2-1 in extra innings, 4-2, and 12-4. They also recently won over Philadelphia 11-2, completing an impressive run over their last five games.
The Cubs are hitting .251 with 117 runs, 187 hits, and 25 home runs. They have posted a .342 on-base percentage and a .399 slugging percentage. On the pitching side, Chicago carries a 3.47 ERA and a 1.16 WHIP, while limiting opponents to a .225 batting average. The staff has recorded 182 strikeouts and issued 67 walks.
One of the biggest strengths for Chicago is its overall balance. The combination of a higher batting average, more runs scored, and a lower ERA compared to Philadelphia shows a team that has been effective on both sides of the game.
Philadelphia Phillies vs Chicago Cubs Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bruce Marshall | +6,749.00 |
| 2 |  Bryan Power | +5,537.00 |
| 3 |  Tony Karpinski | +4,340.00 |
| 4 |  Pro Sports Picks | +3,905.00 |
| 5 |  The Gold Sheet | +2,237.00 |
Philadelphia Phillies vs Chicago Cubs Pick
Pick: Chicago Cubs Moneyline
Chicago enters this matchup with a clear advantage based on both recent performance and overall team statistics. The Cubs have been winning consistently, including multiple recent victories over Philadelphia, and they also hold the edge in batting average, runs scored, and pitching efficiency. With a 3.47 ERA compared to Philadelphia’s 4.87, Chicago’s pitching staff has been more reliable. That combination of recent success and stronger overall numbers makes the Cubs the preferred side in this game.
Philadelphia Phillies vs Chicago Cubs Total Pick
Pick: Take the over if the total is set at 8
I would lean toward the over in this matchup based on the recent scoring trends between these teams. Chicago has been producing offensively, as seen in recent wins over Philadelphia, and the Phillies’ pitching numbers suggest they have struggled to limit runs. While Chicago’s pitching has been more effective overall, the combination of Philadelphia’s defensive issues and Chicago’s offensive production points toward a game that could reach or exceed a typical total around this range.
Final Score Prediction: Chicago Cubs 6 – Philadelphia Phillies 3
This prediction was written before the completion of game play on Tuesday.
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