Pittsburgh Pirates vs Chicago Cubs Picks and Prediction for Saturday September 12 2026
Pirates Preview
Historic Wrigley Field will play host to a Saturday afternoon MLB clash between the Pittsburgh Pirates and the Chicago Cubs. Be ready for the baseball season with all of our MLB predictions. The Pirates (74-74) have won seven of their last ten games and are five games back in the race for the final National League Wild Card spot. On Friday, Pittsburgh DH Bryan Reynolds hit his 17th home run of the year during a 12-2 road loss against Chicago. Rookie SS Konnor Griffin went 2-for-4 and scored a run out of the leadoff spot.
Reigning National League Cy Young Award winner Paul Skenes (10-11 3.83 ERA) will take the mound for the Pirates in this matchup. Through 155 innings of work, Skenes ranks 13th in the majors with 181 strikeouts and sports a 1.15 WHIP.
Cubs Preview
The Chicago Cubs have dropped six of their previous ten games and are sitting in second place in the National League Wild Card standings. During yesterday’s home victory, OF Seiya Suzuki collected three of Chicago’s 16 hits and scored three runs to spark the offense. 1B Michael Busch went 2-for-4 with three RBIs and a pair of runs scored for the Cubs (82-66), who improved to 42-31 at home.
Chicago skipper Craig Counsell will turn to thirty-three year old righty Clay Holmes (6-7 2.83 ERA) on Saturday. In his last start, Holmes (4.1 IP) was roughed up for six hits and eight runs during an ugly 10-3 road loss against Miami.
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Pirates vs Cubs Pick
Chicago SS Dansby Swanson (oblique) is currently on the 10-day injured list and is getting close to starting a rehab assignment. Through 148 games, Pittsburgh ranks 6th in OPS and 5th in runs scored. For the season, Chicago ranks 1st in OPS and 1st in runs scored. The wind will be blowing out to right center at 11 mph. Take the over. Final Score Prediction, Chicago Cubs win 6-5.
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