Pittsburgh Pirates vs Milwaukee Brewers Picks and Predictions for Saturday April 25 2026
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The Pittsburgh Pirates travel to face the Milwaukee Brewers at American Family Field in Milwaukee, Wisconsin on Saturday, April 25, 2026, with first pitch scheduled for 7:10 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. This matchup features two teams with similar records, setting up a competitive game in Milwaukee as both look to gain ground in the standings. For a broader look at today’s action, check out free MLB picks.
Starting Pitchers Preview
Pittsburgh is set to start Mitch Keller, while Milwaukee will counter with Jacob Misiorowski. Keller enters this game with a 2-1 record, posting a 2.79 ERA and a 1.10 WHIP across 29.0 innings. He has allowed 23 hits while striking out 19 batters and walking nine, along with surrendering just one home run. On the other side, Misiorowski comes in with a 1-2 record and a 3.04 ERA, along with a 1.09 WHIP over 26.2 innings. He has allowed 17 hits, struck out 42 batters, walked 12, and given up four home runs, showing strong strikeout ability.
Pittsburgh Bringing Balanced Play into Milwaukee
Pittsburgh enters this contest with a 14-11 overall record and a 6-6 mark on the road. Their recent stretch has been mixed, as they recently lost to Texas but also recently won over Texas and Tampa Bay, along with another recent loss to Texas. This pattern reflects a team that has remained competitive while still working toward consistency.
From a statistical standpoint, the Pirates are hitting .247 with 123 runs and 214 hits, along with 28 home runs. Their .332 on-base percentage and .386 slugging percentage indicate a lineup that can produce offense at a steady rate. On the pitching side, they hold a 3.45 ERA with a 1.29 WHIP, allowing opponents to hit .226 while striking out 234 batters and issuing 103 walks.
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The biggest strength for Pittsburgh is its pitching efficiency. With a lower ERA and a solid opponent batting average, the Pirates have shown they can limit opposing offenses and keep games within reach.
Milwaukee Looking to Hold Ground at Home
Milwaukee comes into this matchup with a 13-11 overall record and a 7-5 mark at home. Their recent stretch has been uneven, as they recently lost to Detroit twice but also recently picked up a win over Detroit and Miami, showing flashes of strong performance mixed with inconsistency.
Statistically, the Brewers are hitting .241 with 124 runs and 193 hits, along with 19 home runs. Their on-base percentage sits at .342, paired with a .368 slugging percentage. On the pitching side, they carry a 3.98 ERA with a 1.33 WHIP, allowing opponents to hit .243 while striking out 212 batters and issuing 91 walks.
The key strength for Milwaukee is its ability to get on base. With a higher on-base percentage than Pittsburgh, the Brewers have shown they can create scoring opportunities even without relying heavily on power.
Pirates vs Brewers Picks and Prediction
Pirates vs Brewers Pick
Pick: Pirates Moneyline
Pittsburgh holds a slight edge in this matchup due to its more efficient pitching staff. With a lower team ERA and opponent batting average, the Pirates have been more effective at limiting opposing offenses. While Milwaukee has been solid at home, Pittsburgh’s balanced approach and ability to control games on the mound give them the advantage in what should be a closely contested matchup.
Pirates vs Brewers Total Pick
Pick: Under 8.5
I’m leaning toward the under in this matchup because both teams have shown solid pitching numbers, particularly Pittsburgh with its lower ERA and opponent batting average. While both offenses are capable of producing, neither team has overwhelming power numbers, which suggests runs may be limited. If both pitching staffs perform to their season averages, this game has the potential to stay under the total.
Final Score Prediction: Pittsburgh Pirates 4 – Milwaukee Brewers 3
This prediction was written before the completion of game play on Friday.
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