Saint Louis Cardinals vs Athletics Picks and Prediction for Wednesday May 13 2026

By: Kim Smith Published 05/13/2026, 12:50 AM ET
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The St. Louis Cardinals travel to Sutter Health Park in Sacramento, California on Wednesday, May 13, 2026, for a matchup against the Athletics. First pitch is scheduled for 9:40 PM ET with coverage available on MLB.TV. St. Louis enters the game with a 23-17 overall record and a strong 13-7 road mark, while the Athletics come in at 21-19 overall and 8-8 at home. The Athletics are listed as -143 favorites on the moneyline while the Cardinals are priced at +119. The total for the game is set at 10 runs with the over at -105 and the under at -115. Be sure to check out our free MLB picks before placing any wagers.

Starting Pitchers Set for Late-Night Matchup

Matthew Liberatore takes the mound for St. Louis carrying a 2-1 record with a 4.07 ERA and a 1.43 WHIP across 42.0 innings. Liberatore has allowed 44 hits while recording 29 strikeouts, issuing 16 walks, and surrendering eight home runs. The Athletics counter with J.T. Ginn, who enters with a 1-1 record, a 3.62 ERA, and a 1.13 WHIP over 37.1 innings. Ginn has allowed 27 hits while striking out 31 batters, walking 15, and allowing five home runs. Based strictly on the provided numbers, the Athletics appear to hold the edge in the starting pitching matchup.

St. Louis Looks to Continue Strong Road Play

The Cardinals enter this contest with a 23-17 overall record and an impressive 13-7 road mark. St. Louis has gone 2-3 over its last five games, recently lost to San Diego 3-2 in 10 innings and recently lost to San Diego 4-2 after previously recently winning over San Diego 6-0 and 2-1. The Cardinals also recently lost to Milwaukee 6-2. Despite the recent losses, St. Louis has continued to compete well away from home throughout the season.

St. Louis is batting .235 with 186 runs, 315 hits, and 46 home runs. The Cardinals own a .318 on-base percentage and a .388 slugging percentage. On the mound, St. Louis carries a 4.25 ERA with a 1.37 WHIP while allowing opponents to hit .251 against them. The pitching staff has also recorded 291 strikeouts with 151 walks this season.

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One key strength for St. Louis entering this matchup is road success combined with power production. The Cardinals have hit 46 home runs this season and have been one of the stronger road teams in this matchup with a 13-7 away record. Their ability to produce offense on the road gives them an opportunity to stay competitive even against a strong Athletics lineup.

Athletics Aim to Stay Consistent at Home

The Athletics enter this matchup with a 21-19 overall record and an even 8-8 mark at home. The Athletics have won three of their last five games, recently won over Baltimore 6-2 and 4-3 while also recently winning over Philadelphia 12-1. They also recently lost to Baltimore 2-1 and recently lost to Philadelphia 6-3. The Athletics have shown the ability to score runs in bunches during recent victories while remaining competitive in lower-scoring games as well.

The Athletics are batting .249 with 176 runs, 340 hits, and 44 home runs. They own a .326 on-base percentage and a .400 slugging percentage. On the pitching side, the Athletics carry a 4.42 ERA with a 1.44 WHIP while allowing opponents to hit .251 against them. The staff has also recorded 321 strikeouts while issuing 174 walks.

The Athletics’ biggest strength entering this game is offensive consistency. They lead this matchup in batting average, hits, on-base percentage, and slugging percentage. The lineup has also shown strong recent production, including a 12-run outburst against Philadelphia during the recent road trip.

St. Louis Cardinals vs Athletics Picks and Prediction

St. Louis Cardinals vs Athletics Pick

  • Pick: Athletics Moneyline

I like the Athletics in this matchup because they enter with the stronger offensive profile and the edge in the starting pitching matchup. J.T. Ginn has posted the lower ERA and WHIP compared to Matthew Liberatore, while the Athletics lineup owns the better batting average, on-base percentage, and slugging percentage. The Athletics have also recently scored six, four, and twelve runs in recent wins, showing strong offensive momentum entering this game.

St. Louis Cardinals vs Athletics Total Pick

  • Pick: Over 10

I would lean toward the over because both teams bring solid power numbers into the matchup while neither pitching staff has particularly dominant overall numbers. St. Louis has hit 46 home runs while the Athletics have added 44. Recent results for both teams have also included higher-scoring games such as 12-1, 6-3, and 6-2. With the total sitting at 10 and both offenses capable of producing runs, the over feels like the better play.

Final Score Prediction: Athletics 7 – St. Louis Cardinals 5

This prediction was written before the completion of game play on Tuesday.

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