San Diego Padres vs Chicago White Sox Picks and Predictions for Friday, September 19, 2025
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The San Diego Padres visit the Chicago White Sox on Friday at Guaranteed Rate Field. The first pitch is scheduled for 7:40 PM ET on MLB.TV. The Padres sit second in the National League West at 83-69, while the White Sox are last in the American League Central at 57-96. San Diego comes in off a 7-4 win over the Mets, while Chicago dropped its fifth straight in a 3-1 loss to Baltimore. San Diego currently holds the second of three NL wild cards, while Chicago has been eliminated from postseason contention. Hit one out of the park with free MLB picks.
San Diego Padres Preview
San Diego has won three of its last five and is trying to lock down a wild card spot. Manny Machado has been the main run producer with 26 homers and 92 RBI, while Luis Arraez leads the club with a .287 average and 168 hits. The Padres’ lineup also benefits from Fernando Tatis Jr.’s blend of power and speed.
On the mound, Dylan Cease gets the start. The right-hander is 8-11 with a 4.59 ERA, 201 strikeouts, and 66 walks in 157 innings. Cease’s strikeout numbers remain strong, but the high walk count has put extra traffic on the bases and created high-scoring innings for opponents on more than one occasion.
Chicago White Sox Preview
Chicago has struggled, dropping nine of its last ten, and has one of the lowest batting averages in the AL. Lenyn Sosa leads the club with 70 RBI and a .261 average, while Andrew Benintendi and Sosa lead the Chisox with 20 homers apiece. The White Sox rank near the bottom of the league in runs scored, as well as in several other statistical categories both related to hitting and pitching.
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Davis Martin is the probable starter for the White Sox. The right-hander holds a 6-10 record with a 4.01 ERA across 132.1 innings. He has allowed 20 home runs, but has done better at keeping his walks to a minimum compared to his counterpart on Friday, Cease.
San Diego Padres vs Chicago White Sox Prediction
The Padres have the better lineup, a deeper bullpen, and an edge with playoff incentives. The White Sox’s recent skid and weak offense give San Diego a big advantage in this matchup. Final Score Prediction: San Diego Padres win 7-2.
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