San Diego Padres vs Chicago White Sox Picks and Predictions for Saturday, September 20, 2025
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The San Diego Padres visit the Chicago White Sox on Saturday at Guaranteed Rate Field with the first pitch at 7:10 PM ET on MLB.TV. San Diego is 83–70 and 3-2 in its last five after a split in New York and two wins over Colorado. Chicago is 57–96 and 0–5 in its last five after three straight losses to Baltimore and two in Cleveland. The Padres are second in the NL West and currently hold the second of three NL wild cards. Chicago has been eliminated from playoff contention. Build your bankroll with our MLB picks.
San Diego Padres Preview
San Diego’s order is steady at the top. Luis Arraez leads with a .287 average and 169 hits, while Manny Machado has 26 home runs, 92 RBI, and a .279 average. Fernando Tatis Jr. adds 22 home runs, 105 runs, and a .369 on-base percentage. As a team, the Padres hit .252 with a .321 on-base percentage and have scored 652 runs with 140 homers. The Padres' road record is 36–42.
Yu Darvish gets the ball. The right-hander is 4–5 with a 5.63 ERA, but a 1.14 WHIP, 60 strikeouts, and 17 walks in 62.1 innings, showing he has good control and limits base runners. The Padres’ staff has been strong overall with a 3.69 ERA and 1.20 WHIP, which has helped them win close games when the bats are quiet.
Chicago White Sox Preview
Chicago has struggled to score. The White Sox sit at .233/.302/.373 with 609 runs. Lenyn Sosa leads in average (.261), home runs (20), and RBI (70). Andrew Benintendi also has 20 home runs and 62 RBI, while Miguel Vargas brings a .308 on-base percentage. Chicago’s home record is 32–46, and the club has dropped five straight with just 11 total runs in that stretch.
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Yoendrys Gomez starts for Chicago. The right-hander is 3–2 with a 4.91 ERA and 1.42 WHIP across 51.1 innings, posting 49 strikeouts but also 27 walks. That walk rate creates extra chances for opponents, and the White Sox staff as a whole carries a 4.23 ERA and 1.36 WHIP. Chicago needs a strong start by Gomez to keep pressure off the bullpen.
San Diego Padres vs Chicago White Sox Prediction
The Padres have the deeper lineup and the better pitching staff. With Darvish keeping runners off base and San Diego’s top bats in good form, the Padres will win a low-scoring game in the Windy City. Final Score Prediction: San Diego Padres win 4-2.
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Best Pick
- San Diego Padres -120
- Under 8.5
