San Diego Padres vs Chicago White Sox Picks and Predictions for Sunday, September 21, 2025
The San Diego Padres visit the Chicago White Sox on Sunday at Guaranteed Rate Field. The first pitch is set for 2:10 PM ET on MLB.TV. The Padres dropped Friday’s game 4-3 but sit third in the NL West. The White Sox picked up that win yet remain last in the AL Central. San Diego trails first in the NL West by four games and currently holds the second of three NL wild cards. Chicago has been eliminated from postseason contention. Go deep with our MLB picks.
San Diego Padres Preview
The Padres come in at 83-71, fighting for a playoff spot but still shaky on the road with a 36-43 record. The Padres have relied on Manny Machado, who has 26 homers and 92 RBI, while Luis Arraez continues to pace the team with a .287 average and 170 hits. Fernando Tatis Jr. adds speed and power with over 100 runs scored.
On the mound, Michael King makes the start. He has a 3.84 ERA with 69 strikeouts in 65.2 innings. The bullpen has been steady, and overall, the Padres rank in the top ten in team ERA at 3.70. San Diego’s starting rotation has kept the team close through the middle innings, and the bullpen has come through more often than not.
Chicago White Sox Preview
The White Sox sit at 58-96, last in the AL Central. Lenyn Sosa has been a bright spot, hitting .261 with 20 home runs and 70 RBI. Andrew Benintendi has also reached the 20-homer mark, but the lineup has struggled for most of the year with a .233 team average. The White Sox have lacked power and have not had timely hitting with runners in scoring position.
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Sean Burke gets the ball for the White Sox with a 4-10 record and a 4.29 ERA. He has 119 strikeouts across 126 innings, but has battled control with 62 walks. Chicago’s pitching staff overall has been up and down, holding a 4.22 ERA. The White Sox have struggled on the mound all season with their starting rotation, and the bullpen has been below-average.
San Diego Padres vs Chicago White Sox Prediction
The Padres have had more success in both hitting and pitching. Even with a losing road record, they have the edge over a White Sox team that has had trouble putting together runs and limiting damage as its pitching staff has struggled with control and WHIP. Final Score Prediction: San Diego Padres win 8-2.
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Best Picks
- San Diego Padres -1.5
- Under 8.5 runs
- Manny Machado to record an RBI
