San Diego Padres vs Cincinnati Reds Picks and Prediction for Wednesday, September 10, 2025

By: Garrett Beaverson Published 09/10/2025, 12:50 AM ET
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The Cincinnati Reds (72–72) conclude their road series in San Diego on Wednesday, September 10, 2025, with first pitch at 8:40 PM ET (5:40 PM PT) from Petco Park. The game will be broadcast on MLBN, FanDuel Sports Network Ohio, and the Padres Television Network. The Reds send Andrew Abbott (8–6, 2.88 ERA) to the mound, while the Padres counter with Nick Pivetta (13–5, 2.85 ERA). Get in on the action with our free MLB picks.

Reds Analysis

Cincinnati enters the matchup at .500 after a painful 4-3 extra-innings loss in the series opener, where they squandered a 3-0 lead and extended their poor extra-innings record to 3–11. Abbott has been one of their steadier arms, consistently delivering quality starts with a sub-3 ERA, offering the best shot to contain San Diego’s offense. The Reds' lineup, led by Elly De La Cruz (19 HR, 81 RBI) and Spencer Steer, who recently homered for the third time in a game, continues to generate sporadic pop but has struggled to support late-game pitching.

Padres Analysis

San Diego improved to 79–65 with a dramatic walk-off win in the series opener, featuring a clutch Fernando Tatis Jr. sac fly and continued offensive contributions from Gavin Sheets. Nick Pivetta anchors their rotation, offering elite consistency and recently elevated stature with a multi-year deal committing him through 2027. The Padres offense, fueled by speed, patience, and timely hitting, should capitalize against a Reds bullpen that has shown vulnerability under pressure.

Standout Players and Key Injuries

  • Cincinnati Reds

    • Andrew Abbott: Reliable lefty with a sub-3 ERA and the ability to keep the lineup competitive.

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    • Elly De La Cruz & Spencer Steer: Offensive catalysts with power and burst in the lineup.

  • San Diego Padres

    • Nick Pivetta: Signed to a multiyear contract, now central to their rotation.

    • Fernando Tatis Jr. & Gavin Sheets: Delivering in key moments and keeping the offense alive.

Key Injuries

  • Reds: Chase Burns (SP) and several pitchers listed day-to-day or on IL; Wade Miley out until at least September 12.

  • Padres: Ethan Salas (C), Nestor Cortes (SP), and Xander Bogaerts (SS) remain on the IL with expected return mid-late September.

Prediction Reasoning

This sets up as a pitchers’ duel between two arms excelling in the second half. Abbott’s consistency gives the Reds a fighting chance, but San Diego’s momentum—boosted by Pivetta’s stability and a potent lineup—tilts the matchup in their favor.

Final Score Projection: Padres 4, Reds 2

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