San Diego Padres vs Cleveland Guardians Picks and Predictions for Sunday, August 16th, 2026

By: Cameron Ross Published 08/16/2026, 12:40 AM ET

Padres vs Guardians Game Information

The San Diego Padres continue their East Coast road trip Sunday with a 1:40 PM matchup in Cleveland, OH, against the Cleveland Guardians. San Diego is 8 games above .500, currently tied for second place in the National League West, following the loss on Saturday to end a winning streak. The Cleveland Guardians stay home Sunday, 4 games below .500, after dropping 3 of their last 5 overall. For more MLB news, see our MLB Picks.

Padres Preview

Wandy Peralta got the start Saturday for San Diego, giving up 1 run on 3 hits through 1 inning of work. Kyle Hart came on in relief to give up 1 run on 1 hit across one inning, leading to the loss. The rest of the San Diego bullpen gave up 4 runs on 7 hits over the final 6 innings. The San Diego offense was terrible on Saturday, compiling just 1 hit in 26 at-bats as a team

Guardians Preview

Joey Cantillo got the start Saturday for Cleveland, giving up 1 run on 1 hit through 6 innings of work, leading to the victory. The Cleveland bullpen was fantastic, giving up no runs on no hits over the final 3 innings of the game. Cleveland had a balanced scoring attack on Saturday, with 4 different players driving in 1 run each.

Padres vs Guardians Pitching Matchup

Casey Mize will get the start Sunday for San Diego. Mize is 4-7 this year with a 3.38 ERA across 96 innings. Tanner Bibbee will be on the mound for the Guardians, trying to get closer to .500. Bibbee is 4-12 with a 3.99 ERA through 144.1 innings.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Padres vs Guardians Pick

The San Diego Padres are the better team in this matchup, playing good baseball lately. San Diego will lean on their edge on both sides of the dish Sunday against a lackluster Cleveland team. Take the Padres Sunday as they get the win on the road in game 3 of this set.

  • Pick: San Diego Padres -112
  • Secondary: Β Over 8.5
  • Lean: Fernando Tatis Jr. Over 1.5 Bases

Final Score Prediction:Β  San Diego Padres win 8-3.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $150 in Bonus Bets *Paid Within 14 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Cashable No
Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.