San Diego Padres vs Colorado Rockies Picks and Predictions for Wednesday April 22 2026
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The San Diego Padres and Colorado Rockies are set to meet at Coors Field in Denver, Colorado on Wednesday, April 22, 2026, with first pitch scheduled for 8:40 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. Make sure to check out our free MLB picks.
Starting Pitchers Taking the Ball
Walker Buehler will start for San Diego, entering with a 1-1 record, a 4.58 ERA, and a 1.25 WHIP across 17.2 innings. He has allowed 16 hits while striking out 18 and walking 6, with 1 home run surrendered. On the other side, Tomoyuki Sugano will take the mound for Colorado with a 1-1 record, a 3.92 ERA, and a 1.16 WHIP over 20.2 innings. He has allowed 19 hits, recorded 15 strikeouts, walked 5, and given up 5 home runs. 
Padres Carrying Strong Road Form into Denver
San Diego enters this matchup with a 15-7 record and a 6-3 mark on the road. The Padres have been playing well recently, recently winning over Los Angeles twice by scores of 2-1 and 4-1. They also recently won over Seattle and picked up another victory against Seattle, while recently losing an 8-0 game to Los Angeles in that same stretch. Overall, that run shows a team that has been able to secure wins consistently while maintaining a strong overall record.
From a statistical standpoint, San Diego is hitting .232 with 96 runs, 168 hits, and 17 home runs. The Padres have posted a .310 on-base percentage and a .369 slugging percentage. On the pitching side, they carry a 3.36 ERA and a 1.23 WHIP, while holding opponents to a .231 batting average. The staff has recorded 212 strikeouts and issued 76 walks.
One of the biggest strengths for San Diego has been its pitching. The 3.36 ERA and .231 opponent batting average highlight a staff that has been effective at limiting opposing offenses and keeping games within reach.
Rockies Hoping to Respond at Home
Colorado comes into this contest with a 9-14 record and a 6-4 mark at home. The Rockies recently lost to Los Angeles 12-3 but had some positive results prior to that, recently winning over Los Angeles twice with scores of 9-6 and 4-3. They also recently lost to Los Angeles 7-1 and picked up a 3-2 victory against Houston. That mix of results shows a team that has had moments of success but has struggled with consistency overall.
Offensively, Colorado is hitting .244 with 92 runs, 188 hits, and 23 home runs. The Rockies have posted a .310 on-base percentage and a .390 slugging percentage. On the pitching side, they hold a 4.40 ERA and a 1.42 WHIP, while allowing opponents to hit .268. The staff has recorded 170 strikeouts and issued 77 walks.
A key concern for Colorado is its pitching performance. The higher ERA, WHIP, and opponent batting average indicate that opposing teams have been able to generate offense consistently, which has made it difficult to maintain control in games.
San Diego Padres vs Colorado Rockies Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bruce Marshall | +6,749.00 |
| 2 |  Bryan Power | +5,537.00 |
| 3 |  Tony Karpinski | +4,340.00 |
| 4 |  Pro Sports Picks | +3,905.00 |
| 5 |  The Gold Sheet | +2,237.00 |
San Diego Padres vs Colorado Rockies Pick
Pick: San Diego Padres Moneyline
San Diego enters this matchup with a clear edge in pitching, which stands out as the deciding factor. The Padres’ 3.36 ERA and .231 opponent batting average compare favorably to Colorado’s higher numbers, and that difference suggests San Diego is better equipped to control the game. While Colorado has shown the ability to score, the Padres’ pitching efficiency provides a strong foundation, especially when combined with their solid overall record.
San Diego Padres vs Colorado Rockies Total Pick
Pick: Take the over if the total is set at 9
I would lean toward the over in this matchup based on Colorado’s pitching struggles and San Diego’s ability to produce runs when needed. The Rockies’ 4.40 ERA and higher WHIP indicate that opposing teams have found scoring opportunities, and San Diego has been capable of taking advantage of those situations. At the same time, Colorado has shown it can score in certain games, which creates a path for both teams to contribute to the total.
Final Score Prediction: San Diego Padres 6 – Colorado Rockies 4
This prediction was written before the completion of game play on Tuesday.
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