San Diego Padres vs New York Mets Picks and Predictions for Wednesday, September 17, 2025

By: David Anicetti Published 09/17/2025, 12:10 AM ET
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The San Diego Padres visit the New York Mets on Wednesday at Citi Field with the first pitch scheduled for 7:10 PM ET on MLB.TV. San Diego comes in 82–68 with a 35–40 road record. New York is 77–73 and 46–29 at home. The starting matchup is San Diego right-hander Nick Pivetta against New York left-hander David Peterson. San Diego is second in the National League West, trailing LA by two games, and is second in the NL wild card race. New York is barely clinging to the third and final NL wild card spot by 1.5 games. Round the bases and score with our MLB picks.

San Diego Padres Preview

Nick Pivetta has been excellent this season, posting a 13–5 record with a 2.73 ERA and a 0.95 WHIP in 171.1 innings. He has 180 strikeouts while keeping hits and homers down, which gives the Padres a solid chance most times he takes the mound. As a team, San Diego has pitched well all year, carrying a 3.64 ERA and 1.20 WHIP while holding opponents to a .225 average.

Offensively, San Diego has been steadier, rather than explosive. The Padres are hitting .252 with a .321 on-base percentage and .388 slugging percentage while scoring 641 runs with 135 homers. Manny Machado leads the way with 25 home runs and 88 RBI, while Luis Arraez makes contact and has a .286 average. Fernando Tatis Jr. adds power with 22 home runs and an on-base percentage of .367. San Diego has won three of its last five, including two high-scoring games against Colorado.

New York Mets Preview

David Peterson enters 9–5 with a 3.77 ERA and a 1.32 WHIP over 162.1 innings. He’s given up only 10 homers while striking out 148, showing he stays away from long innings. The Mets’ staff overall holds a 4.01 ERA and 1.34 WHIP, and Peterson has been one of the more consistent arms for the Mets all season.

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The Mets’ bats have more power than San Diego’s. New York is hitting .249/.327/.426 with 203 home runs and 704 runs scored. Juan Soto leads with 40 homers and a .396 on-base percentage, Pete Alonso has 34 homers with 117 RBI, and Francisco Lindor chips in 26 homers with over 100 runs scored. Despite losing four of the last five before edging Texas in extras, the Mets remain strong at Citi Field with a 46–29 home mark.

San Diego Padres vs New York Mets Prediction

The best bet here is San Diego. Pivetta’s control and strikeout ability give San Diego the advantage in this game. Peterson has done well at home, but the Padres’ pitching staff and strong contact-hitting lineup give them the better chance than the Mets' power-hitting lineup. Final Score Prediction: San Diego Padres win 5-3.

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