San Francisco Giants vs Arizona Diamondbacks Picks and Prediction for Wednesday May 20 2026
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The San Francisco Giants travel to face the Arizona Diamondbacks on Wednesday May 20, 2026, at Chase Field in Phoenix, Arizona. First pitch is scheduled for 3:40 PM ET with coverage on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.
Starting Pitchers
Tyler Mahle is expected to start for San Francisco in this matchup. The right-hander enters the game with a 1-5 record, a 5.59 ERA, and a 1.56 WHIP across 46.2 innings pitched. He has allowed 52 hits while recording 48 strikeouts and 21 walks with nine home runs surrendered. Arizona is expected to counter with Merrill Kelly, who enters with a 3-3 record, a 5.91 ERA, and a 1.54 WHIP over 35.0 innings. He has allowed 36 hits while striking out 23 batters and walking 18 while giving up seven home runs.
Giants Looking to Recover After Lopsided Loss
San Francisco enters Wednesday with a 20-28 overall record and a 10-16 road record. The Giants recently lost to Arizona 12-2 after recently winning over Oakland by scores of 10-1 and 6-4. San Francisco also recently lost to Oakland 5-2 and recently lost to Los Angeles 5-2 during this stretch. The Giants have struggled away from home this season and continue searching for more consistency during road games.
The Giants are batting .244 as a team with 167 runs scored and 401 hits this season. San Francisco has hit 38 home runs while posting a .292 on-base percentage and a .376 slugging percentage. On the mound, the Giants own a 4.11 ERA and a 1.34 WHIP while allowing opponents to hit .244 against them. The pitching staff has also issued 182 walks and recorded 375 strikeouts this year.
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One concern for San Francisco entering this matchup is offensive consistency. Despite matching Arizona with a .244 team batting average, the Giants have scored only 167 runs this season, significantly fewer than the Diamondbacks. San Francisco has also struggled on the road with only 10 road victories entering Wednesday’s contest.
Diamondbacks Building Momentum at Home
Arizona enters this game with a 23-23 overall record and a strong 13-9 home record. The Diamondbacks recently won over San Francisco 12-2 after recently winning over Colorado by scores of 8-6 and 9-1. Arizona recently lost to Colorado 4-2 and recently lost to Texas 6-5 during this recent stretch, but the offense has continued producing solid numbers overall.
The Diamondbacks are batting .244 as a team with 210 runs scored and 374 hits this season. Arizona has hit 42 home runs while posting a .309 on-base percentage and a .400 slugging percentage. On the mound, the Diamondbacks carry a 4.33 ERA and a 1.28 WHIP while opponents are batting .243 against them. Arizona has also issued 142 walks and recorded 340 strikeouts this season.
One major strength for Arizona entering this matchup is offensive production. The Diamondbacks have scored 210 runs this season compared to San Francisco’s 167 and recently exploded for 12 runs in the series opener. Arizona also owns the better slugging percentage while continuing to produce power consistently at home.
San Francisco Giants vs Arizona Diamondbacks Picks and Prediction
San Francisco Giants vs Arizona Diamondbacks Pick
- Pick: Arizona Diamondbacks Moneyline
Arizona enters this matchup with stronger recent offensive momentum after the 12-2 victory over San Francisco in the series opener. The Diamondbacks also own the better home record and have scored significantly more runs this season than the Giants. San Francisco has struggled away from home while continuing to search for offensive consistency. With Arizona producing strong offensive numbers and holding the advantage at home, the Diamondbacks appear to have the edge entering Wednesday.
San Francisco Giants vs Arizona Diamondbacks Total Pick
- Pick: Take the over if the total is set at 9.5
I would lean toward the over because both starting pitchers enter with ERA numbers above 5.50 and both teams recently combined for 14 runs in the series opener. Arizona’s offense has been productive recently, scoring 12 runs against San Francisco and at least eight runs in two other recent games. The Giants pitching staff has also allowed multiple high-scoring games during this road trip. With both pitchers allowing consistent baserunners and home runs this season, this matchup could turn into another offensive game.
Final Score Prediction: Arizona Diamondbacks 7 – San Francisco Giants 4
This prediction was written before the completion of game play on Tuesday.
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