San Francisco Giants vs Cincinnati Reds Picks and Prediction for Thursday April 16 2026

Giants Preview

The Great American Ball Park will play host to a Thursday afternoon MLB clash between the San Francisco Giants and the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The Giants (6-12) are looking to snap a four-game losing streak and are trapped in the NL West Division basement. Last night, San Francisco SP Tyler Mahle (0-3) was tagged for eight runs in four innings during an 8-3 road loss against Cincinnati.

Twenty-seven year old righty Landen Roupp (2-1 3.24 ERA) will take the mound for the Giants in this matchup. Last time out, Roupp (6 IP) allowed one run and struck out four batters during a 6-3 road victory against Baltimore.

Reds Preview

The Cincinnati Reds are a game above .500 at home and are seeking their first NL Central Division title since 2012. During Wednesday’s home victory, 1B Sal Stewart crushed two long balls and drove in six runs to power the Cincinnati offense. Elly De La Cruz and Eugenio Suarez also went deep for the Reds (11-7), who moved into a first place tie with Pittsburgh.

Twenty-three year old righty Chase Burns (1-1 3.31 ERA) has the potential to win a strikeout crown for the Reds in the future. Through 16 plus innings, Burnes has retired 18 batters by strikes and owns a respectable 1.29 WHIP.

Giants vs Reds Pick

Cincinnati SP Hunter Greene is recovering from arthroscopic elbow surgery and hopes to make his season debut in early July. Through 18 games, San Francisco ranks 26th in OPS and 30th in runs scored. For the season, Cincinnati ranks 29th in OPS and 27th in runs scored. Take the under. Final Score Prediction, Cincinnati Reds win 4-3.

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