San Francisco Giants vs St. Louis Cardinals Picks and Predictions for Sunday, September 7, 2025
Giants vs Cardinals Game Information
The San Francisco Giants will be on the road again Sunday for game three of three in Busch Stadium against the St. Louis Cardinals. The game is slated for a 2:15 PM EST start time to conclude the matchup between the Giants and Cardinals this season. San Francisco is 72-69 on the year, riding a lengthy winning streak following a six-run victory against Saint Louis in Game 1 of this series. St. Louis is two games below .500 at 70-72 on the year after losing 3 of the last five overall. Stay in the action with our MLB Picks.
Giants Preview
Willy Adames is one of the top bats in the San Francisco line this season, leading the team with 27 home runs and 78 RBI's overall. Heliot Ramos is the top bat in the lineup with a .269 batting average this season. As a team, San Francisco has a .239 batting average and has scored 613 runs on 1126 hits as a team. 
Cardinals Preview
The St. Louis Cardinals offense has been stout this season, with a .246 batting average, having scored 615 runs on 1171 hits. Alec Burleson is the top bat in the Saint Louis offense this season with a .286 batting average on the year. Willson Contreras has supplied the most power for Saint Louis this season, leading the team with 20 home runs and 78 RBI overall.
Giants vs Cardinals Pitching Matchup
Kai-Wei Teng will take the ball Sunday for San Francisco, looking to improve on a below-average season. For the year, Tang has two wins and three losses and a 7.213 ERA across 18.2 innings of work. Sonny Gray will counter for Saint Louis as one of the better pitchers on the roster. Gray has twelve wins and eight losses this season to go along with a 4.43 ERA in just over 158 innings on the mound.
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Giants vs Cardinals Pick
This game is much more important for San Francisco, as they still have a potential shot at a playoff berth. San Francisco is four games back in the wild card and will do the work Sunday to get the win. Take the Giants to pull off another road win in Saint Louis Sunday to close their series against the Cardinals.
Pick: Giants -1.5
Secondary: Over
Lean: Willy Adames RBI
Final Score Prediction: San Francisco Giants win and cover 8-3.
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