Seattle Mariners vs Houston Astros Picks and Predictions for Sunday, September 21, 2025
The Seattle Mariners visit the Houston Astros on Sunday at Daikin Park. 7:00 PM ET on ESPN. Seattle has won four of its last five, including a 4–0 win here on Friday, and sits first in the AL West. Houston had won three straight before Friday’s loss and sits second in the AL West. Seattle and Houston are still battling for a postseason berth. The Mariners lead the AL West while Houston is clinging to the third and final AL wild card. Our MLB picks will make you a winner today.
Seattle Mariners Preview
Seattle is 85–69 and 37–42 on the road. Cal Raleigh leads the Mariners at the plate with 56 home runs and 118 RBI, while Julio Rodríguez is batting .269 with 169 hits. Randy Arozarena has 27 homers. The Mariners have 227 homers with a .244 average and a .320 on-base percentage. The Mariners use a mix of power and timely hitting.
Logan Gilbert starts for Seattle on Sunday, with a 3.53 ERA, 1.05 WHIP, and 164 strikeouts in 120.0 innings. Gibert has a strong fastball, and his walk rate is low (29), which often results in innings being very short. Seattle’s staff holds a 3.89 ERA and 1.23 WHIP, and the club is 52–49 at night.
Houston Astros Preview
Houston is 84–70 and 46–33 at home. Jeremy Peña leads the club in average at .303 with 148 hits, Jose Altuve has 26 homers and a .261 mark, and Christian Walker adds 23 homers and 82 RBI. The Astros hit .251/.317/.398 with 169 home runs, which includes a mix of contact hitting and power, that has brought the Astros close to a postseason berth.
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Jason Alexander goes for Houston with a 4.04 ERA, 1.30 WHIP, and 60 strikeouts across 71.1 innings. He limits big innings when keeping the slider down. The Astros’ staff has been solid (3.83 ERA, 1.22 WHIP) and the team is 57–47 at night, but they were shut out by Seattle on Friday and will need early base runners to attack Gilbert..
Seattle Mariners vs Houston Astros Prediction
Seattle holds the recent form edge and brings the higher strikeout arm in Gilbert against the Houston lineup. With Raleigh’s power and Rodríguez setting the table, the Mariners have the edge in this matchup, although the two have been competitive head-to-head all season. Final Score Prediction: Seattle Mariners win 4-3.
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- Seattle Mariners +105
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