Seattle Mariners vs Kansas City Royals Picks and Predictions for Wednesday, September 17, 2025

By: Cameron Ross Published 09/17/2025, 12:45 AM ET
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Mariners vs Royals Game Information

The Seattle Mariners wrap a road trip in Kansas City on Wednesday night with a game in Kauffman Stadium against the Kansas City Royals at 7:40 PM. Seattle was battling for the top spot in the American League West, currently the number one overall seed, riding a lengthy winning streak, coming into their series against Kansas City. The Kansas City Royals have been mediocre all year with 75 wins and 75 losses overall, currently 10 games back in the American League Central. Stay in the loop with our MLB Picks.

Mariners Preview

Julio Rodriguez leads the way for the Seattle offense this season with a .229 batting average. Cal Raleigh has supplied the power to the Seattle offense with 54 home runs and 115 RBI's. As a unit, Seattle has been stout all season with a .244 batting average, having scored 705 runs on 1242 hits.

Royals Preview

Maikel Garcia leads the Kansas City offense this season with a .293 batting average. Vinnie Pasquantino Supplies power for Kansas City this season, leading the way with 30 home runs and 104 RBI's. The Kansas City offense has been solid enough this season with a .244 batting average, but the Royals have scored just 577 thousand 1219 total hits.

Mariners vs Royals Pitching Matchup

Bryce Miller will take the mound on Wednesday for Seattle. Miller has four wins and five losses with a 5.59 ERA across 75.2 innings of work. Cole Ragans will be on the mound for Kansas City Wednesday night in the series finale. Reagan has a 5.18 ERA and a 2-3 record across 48.2 innings of work.

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Mariners vs Royals Pick

This game is much more important for Seattle as they are fighting for playoff seeding. Look for Seattle to do the work on both sides of the plate, as they are the better overall team. Take the Mariners on Wednesday night to do the work as they get the victory on the road in Kansas City.

Pick: Seattle Mariners -110

Secondary: Over

Lean: Cal Raleigh RBI

Final Score Prediction: Seattle Mariners win 7-3

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