Seattle Mariners vs San Diego Padres Picks and Predictions for Thursday, April 16, 2026
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The Seattle Mariners visit the San Diego Padres at Petco Park on Thursday, April 16, at 8:40 PM ET on MLB.TV/MLB Network. Seattle is 8-10, fourth in the AL West, while San Diego is 11-6 and second in the NL West. The Mariners lost 4-1 to the Padres in the opening game of this series. This is the third and final game of the series, with the second game played after this article was written on Thursday. Cash in a winner with our free MLB picks.
Seattle Mariners Preview
The Mariners are coming off a 4-1 loss to San Diego, snapping a four-game winning streak. Seattle had been playing well before that result, winning four straight against Houston, but struggled to generate offense in the series opener.
Seattle is hitting .205 with a .313 on-base percentage and .332 slugging percentage. Luke Raley leads the team with a .296 average, three home runs, and 10 RBI, while Brendan Donovan has a .417 OBP. Randy Arozarena leads with 18 hits, giving the lineup some balance despite overall struggles.
Pitching has been the strength. The Mariners have a 3.02 ERA and 1.06 WHIP, allowing a .231 opponent batting average with just 38 walks and 152 strikeouts. The ability to limit baserunners and generate strikeouts has kept Seattle competitive, even when the offense has been inconsistent.
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Injuries: Miles Mastrobuoni, 10-Day IL, Rob Refsnyder, Paternity, Victor Robles, 10-Day IL, Bryce Miller, 15-Day IL, Teddy McGraw, Out
San Diego Padres Preview
The Padres' win over Seattle on Tuesday was their sixth straight. San Diego has been one of the more consistent teams early in the season, combining solid pitching with timely offense, but is two games behind first-place Los Angeles in the NL West.
San Diego is hitting .233 with a .310 on-base percentage and .388 slugging percentage. Ramon Laureano leads the team with a .283 batting average, four home runs, and 11 RBI, while Xander Bogaerts also has 11 RBI. Manny Machado has a .368 on-base percentage, but has not hit for power consistently as of yet.
On the mound, San Diego has a 3.27 ERA and 1.19 WHIP while allowing a .231 batting opponent average. The staff has been effective at limiting runs and has supported the offense by holding opponents to fewer runs during the current winning streak.
Injuries: Yuki Matsui, 15-Day IL, Sung-Mun Song, 10-Day IL, Matt Waldron, 15-Day IL, Blake Hunt, 7-Day IL, Will Wagner, 10-Day IL
Pitching Matchup
Seattle Mariners – Luis Castillo
Castillo is 0-0 with a 6.92 ERA and 1.77 WHIP over 13.0 innings. He has allowed 19 hits and has struggled to limit baserunners early in the season.
San Diego Padres – Walker Buehler
Buehler is 0-1 with a 4.97 ERA and 1.26 WHIP across 12.2 innings. He has allowed 11 hits with 11 strikeouts and five walks.
Seattle Mariners vs San Diego Padres Prediction
San Diego has the advantage with better recent form and a more consistent offense. The Padres have been able to generate enough scoring while maintaining solid pitching, which has carried them during their current winning streak. Seattle’s pitching will keep the game competitive, but Castillo’s early struggles could create problems for the Mariners. With the Padres playing well at home, they are in a strong position to win again. Final Score Prediction: San Diego Padres win 5-3.
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