St. Louis Cardinals vs. Arizona Diamondbacks Picks and Prediction for Saturday, July 18, 2026

By: David Anicetti Published 07/18/2026, 12:10 AM ET
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The St. Louis Cardinals continue their road series against the Arizona Diamondbacks on Saturday at 4:10 p.m. ET at Chase Field. St. Louis is 50-45 and sits third in the NL Central, while Arizona is 49-47 and ranks second in the NL West. The Cardinals are 3-2 over their last five games after splitting series against Milwaukee and Atlanta, while the Diamondbacks have won four of their last five, including four straight victories during their road trip through San Diego and Los Angeles. Arizona leads the season series 2-1 entering this matchup. Be a winner with our free MLB picks.

St. Louis Cardinals Preview

St. Louis has produced a balanced offense this season, batting .242 while scoring 429 runs with 107 home runs and a .318 on-base percentage. Jordan Walker has enjoyed a breakout campaign, hitting .294 with 22 home runs, 74 RBI and 105 hits. Alec Burleson has added 15 home runs and 67 RBI, while JJ Wetherholt is batting .259 with 13 home runs. Ivan Herrera continues to reach base at a high rate with a .381 on-base percentage.

The Cardinals have stayed in the playoff race behind a dependable pitching staff. St. Louis ranks 12th in MLB with a 4.13 ERA and a 1.33 WHIP while holding opponents to a .251 batting average. The staff has totaled 715 strikeouts across 848.2 innings and continues to provide consistent outings despite dealing with injuries.

Injuries: Ramon Urias (60-Day IL), Max Rajcic (60-Day IL).

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Arizona Diamondbacks Preview

Arizona has scored 416 runs while batting .237 with 89 home runs and a .307 on-base percentage. Ketel Marte leads the offense with a .256 average, 17 home runs and 54 RBI, while Corbin Carroll has contributed 13 home runs and 45 RBI. Gabriel Moreno has been one of the club's most consistent hitters, batting .301 with a .385 on-base percentage, and Ildemaro Vargas is hitting .258 with 47 RBI.

The Diamondbacks have been competitive because of steady pitching. Arizona ranks 15th in MLB with a 4.21 ERA and a 1.27 WHIP while limiting opponents to a .249 batting average. The staff has allowed only 273 walks this season, helping keep runners off base despite recording just 655 strikeouts.

Injuries: Blake Walston (60-Day IL), Tommy Troy (10-Day IL), Michael Soroka (15-Day IL), Zac Gallen (15-Day IL). Geraldo Perdomo is day-to-day.

Pitching Matchup

St. Louis Cardinals – Undecided

The Cardinals had not announced a starting pitcher at the time of this preview. St. Louis could turn to a spot starter or a bullpen game.

Arizona Diamondbacks – Brandon Pfaadt (RHP)

Pfaadt is 3-1 with a 4.70 ERA and a 1.32 WHIP over 53.2 innings this season. He has allowed 53 hits while striking out 41 batters and has won each of his last three decisions.

St. Louis Cardinals vs. Arizona Diamondbacks Prediction

Arizona enters with the momentum after winning four straight games and returns home with Brandon Pfaadt facing a Cardinals club that has yet to name a starter. St. Louis has more power throughout its lineup, but the uncertainty on the mound gives the Diamondbacks an advantage. Expect another competitive game, with Arizona doing enough late to continue its strong stretch. Final Score Prediction: Arizona Diamondbacks win 5-4.

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