St. Louis Cardinals vs Athletics Picks and Prediction for Tuesday May 12 2026

By: Kim Smith Published 05/12/2026, 01:15 AM ET
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The St. Louis Cardinals travel to Sutter Health Park in Sacramento, California, to take on the Athletics on Tuesday, May 12, 2026. First pitch is scheduled for 9:40 PM with television coverage available on ESPN Unlmtd and MLB.TV. At the time of this writing the odds were not released. This matchup features two teams playing solid baseball recently, with St. Louis carrying one of the stronger road records in the league while the Athletics attempt to continue building momentum at home. You can also check out free MLB picks for more baseball predictions and betting analysis.

Starting Pitchers Set for Late-Night Matchup

St. Louis is expected to start Andre Pallante, who enters with a 3-3 record, a 4.34 ERA, and a 1.37 WHIP across 37.1 innings. He has allowed 35 hits while striking out 29 batters, walking 16, and surrendering five home runs. The Athletics counter with Jeffrey Springs, who comes into the matchup with a 3-2 record, a 3.89 ERA, and a 1.14 WHIP over 44.0 innings. He has allowed 38 hits while recording 39 strikeouts, issuing 12 walks, and giving up seven home runs.

St. Louis Continues Strong Road Form

St. Louis enters Tuesday night with a 23-17 overall record and an impressive 13-7 road record. The Cardinals recently lost to San Diego 3-2 in 10 innings and recently lost to San Diego 4-2 after recently won over San Diego 6-0 and recently won over San Diego 2-1. Before that series, St. Louis recently lost to Milwaukee 6-2. The Cardinals have won two of their last five games overall but have remained competitive throughout a difficult recent stretch on the road.

The Cardinals are batting .235 as a team with 186 runs, 315 hits, and 46 home runs. St. Louis owns a .318 on-base percentage and a .388 slugging percentage. On the pitching side, the Cardinals carry a 4.25 ERA with a 1.37 WHIP, 151 walks, 291 strikeouts, and a .251 opponent batting average. St. Louis is also 16-6 in night games this season.

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One major strength for St. Louis is power production combined with road success. The Cardinals have already hit 46 home runs and scored 186 runs while maintaining a strong 13-7 away record. The concern entering this matchup is overall pitching consistency, as the Cardinals enter with a .251 opponent batting average and a WHIP above 1.30.

Athletics Look to Stay Hot at Home

The Athletics enter this matchup with a 21-19 overall record and an 8-8 home mark. The Athletics recently lost to Baltimore 2-1 after recently won over Baltimore 6-2 and recently won over Baltimore 4-3. Before that series, the Athletics recently won over Philadelphia 12-1 before recently lost to Philadelphia 6-3. The Athletics have won three of their last five games overall and have shown offensive upside during that stretch.

The Athletics are batting .249 with 176 runs, 340 hits, and 44 home runs. The Athletics also carry a .326 on-base percentage and a .400 slugging percentage. On the pitching side, the Athletics own a 4.42 ERA with a 1.44 WHIP, 174 walks, 321 strikeouts, and a .251 opponent batting average. The Athletics are also 12-10 in night games this season.

The biggest strength for the Athletics is offensive efficiency. The Athletics enter with the better batting average, on-base percentage, and slugging percentage compared to St. Louis. The lineup has also shown recent scoring capability, including a 12-run performance against Philadelphia. However, the pitching staff has struggled with control, issuing 174 walks already this season.

St. Louis Cardinals vs Athletics Picks and Prediction

St. Louis Cardinals vs Athletics Pick

  • Pick: St. Louis Cardinals Moneyline

St. Louis gets the lean because the Cardinals have been one of the stronger road teams provided, carrying a 13-7 away record into this matchup. The Cardinals also hold the edge in home run production and overall runs scored while facing an Athletics pitching staff with a 1.44 WHIP and 174 walks allowed. Even though the Athletics have played solid baseball recently, St. Louis has consistently remained competitive against strong opponents and looks slightly more balanced entering this contest.

St. Louis Cardinals vs Athletics Total Pick

  • Pick: Over 8.5

I would take the over 8.5 because both teams have shown the ability to score runs consistently while also carrying pitching concerns. St. Louis has hit 46 home runs and scored 186 runs, while the Athletics own a .249 batting average with 44 home runs. Both pitching staffs also enter with ERAs above 4.20 and WHIPs above 1.35. Recent games for both clubs have included strong offensive performances, including the Athletics scoring 12 runs against Philadelphia and the Cardinals scoring six against San Diego.

Final Score Prediction: St. Louis Cardinals 6 – Athletics 5

This prediction was written before the completion of game play on Monday.

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