St. Louis Cardinals vs Chicago Cubs Picks and Prediction for Saturday September 27 2025

By: Eddie Kline Published 09/27/2025, 12:55 AM ET

Cardinals Preview

NL Central Division rivals will collide on Saturday afternoon, when the St. Louis Cardinals and the Chicago Cubs continue their series from Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The Cardinals (78-82) are 11 games below .500 on the road and have been eliminated from postseason contention. On Friday, St. Louis 2B Nolan Gorman went 2-for-4 with a run scored during an ugly 12-1 road loss.

Twenty-five year old righty Michael McGreevy (8-3 4.35 ERA) will take the mound for the Cardinals in this matchup. In his last start, McGreevy (5 IP) gave up six hits and five runs during a 6-5 road victory against San Francisco.

Cubs Preview

The Chicago Cubs have won 48 of 79 home games and are sitting in second place in the NL Wild Card standings. During yesterday’s home victory, All-Star OF Pete Crow-Armstrong’s two-run blast staked Chicago to a 3-0 advantage. OF Seiya Suzuki capped the scoring with a grand slam for the Cubs, who improved to 90-70 overall.

Thirty-three year old righty Jameson Taillon (10-7 3.78 ERA) has been peaking at the right time for the Cubs. Over his previous five starts, Taillon has surrendered just one long ball and five earned runs across 28 plus frames.

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Cardinals vs Cubs Pick

St. Louis SS Masyn Winn suffered a meniscus tear in his right knee and will miss the remainder of the season. Through 160 games, St. Louis ranks 24th in OPS and 18th in runs scored. For the season, Chicago ranks 8th in OPS and 8th in runs scored. Take the over. Final Score Prediction, Chicago Cubs win 7-4.

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