St. Louis Cardinals vs Cincinnati Reds Picks and Prediction for Saturday May 23 2026
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The St. Louis Cardinals travel to face the Cincinnati Reds on Saturday, May 23, 2026, at Great American Ball Park in Cincinnati, Ohio. First pitch is scheduled for 7:15 PM ET with television coverage available on MLB.TV and FOX. St. Louis enters the matchup with a 28-21 overall record and a strong 15-8 road mark, while Cincinnati comes in at 26-24 with a 13-11 home record. According to ESPN Analytics, the Reds hold a slight edge in the matchup at 53.0 percent. Be sure to check out our free MLB picks
Starting Pitchers Preview
Andre Pallante takes the mound for St. Louis carrying a 4-4 record with a 4.04 ERA and a 1.35 WHIP across 49.0 innings this season. He has allowed 47 hits and six home runs while recording 40 strikeouts. Cincinnati counters with Brady Singer, who enters with a 2-4 record and a 6.26 ERA over 46.0 innings. Singer has allowed 66 hits and 14 home runs this season while posting a 1.70 WHIP with 34 strikeouts.
St. Louis Looking to Regain Momentum
St. Louis enters this contest with a 28-21 overall record and has played well away from home with 15 wins in 23 road games. The Cardinals recently lost to Pittsburgh by scores of 6-2 and 7-0 after previously recently won over Pittsburgh 9-6 in extra innings. Before that series, St. Louis recently lost to Kansas City 2-0 but also recently won over the Royals 4-2. The Cardinals have alternated between strong offensive performances and quieter games during the last week.
The Cardinals are batting .240 as a team with 219 runs scored, 395 hits, and 56 home runs this season. St. Louis owns a .320 on-base percentage and a .389 slugging percentage while carrying a 4.24 ERA and a 1.38 WHIP. Opponents are hitting .257 against Cardinals pitching, and the staff has recorded 358 strikeouts this season.
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One key strength for St. Louis entering this matchup is power production. The Cardinals have already hit 56 home runs this season and have shown the ability to generate offense quickly during victories. While consistency has been an issue recently, the lineup still carries enough power to pressure opposing pitching staffs.
Cincinnati Trying to Extend Strong Road Stretch
Cincinnati comes into this game with a 26-24 overall record and has been solid at home with a 13-11 mark. The Reds recently won over Philadelphia by scores of 9-4 and 4-1 after previously recently lost to Philadelphia 5-4. Before that series, Cincinnati recently lost to Cleveland by scores of 10-3 and 7-4. The Reds have scored at least four runs in three straight games entering this matchup and appear to be finding offensive rhythm again.
The Reds are batting .229 as a team with 221 runs scored, 384 hits, and 63 home runs this season. Cincinnati owns a .312 on-base percentage and a .394 slugging percentage while carrying a 4.71 ERA and a 1.46 WHIP. Reds pitchers have recorded 389 strikeouts this season while allowing opponents to hit .248 against them.
One area that stands out for Cincinnati is home run production. The Reds have already hit 63 home runs this season, which is more than St. Louis entering this matchup. Even with the lower batting average overall, Cincinnati has consistently created scoring opportunities through power hitting.
St. Louis Cardinals vs. Cincinnati Reds Picks and Prediction
St. Louis Cardinals vs. Cincinnati Reds Pick
- Pick: St. Louis Cardinals Moneyline
St. Louis enters this matchup with the stronger overall record and better pitching numbers. The Cardinals own the lower ERA and WHIP entering this game, while Cincinnati’s starting pitching numbers have struggled significantly this season. St. Louis has also been strong on the road with a 15-8 record away from home. While Cincinnati has shown improved offense recently, the Cardinals appear to have the more balanced overall profile entering Saturday night.
St. Louis Cardinals vs. Cincinnati Reds Total Pick
- Pick: Over 9.5
I would lean toward the over because both pitching staffs have allowed scoring opportunities consistently this season. Cincinnati carries a 4.71 ERA while St. Louis enters with a 4.24 ERA. The Reds have also hit 63 home runs this year, and the Cardinals have produced 56 of their own. Recent games for both teams have featured offensive production, including Cincinnati scoring 13 runs combined across the last two wins and St. Louis producing nine runs in the recent extra-inning victory over Pittsburgh.
Final Score Prediction: St. Louis Cardinals 6 – Cincinnati Reds 5
This prediction was written before the completion of game play on Friday.
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