St. Louis Cardinals vs Miami Marlins Picks and Predictions for Wednesday April 22 2026
Use Code PPWC
The St. Louis Cardinals and Miami Marlins are set to meet at loanDepot park in Miami, Florida on Wednesday, April 22, 2026, with first pitch scheduled for 12:10 PM and coverage available on MLB.TV. The betting odds show Miami as a -131 favorite on the moneyline, while St. Louis comes in at +109. The total for the game is set at 8.5 runs, with both sides priced near even, and the run line favors the Cardinals at +1.5 (-199) while the Marlins sit at -1.5 (+163). Make sure you check out free MLB picks for more insights.
Starting Pitchers Set the Tone
Kyle Leahy takes the mound for St. Louis with a 2-2 record, carrying a 5.21 ERA and a 1.53 WHIP across 19 innings. He has allowed 21 hits while striking out 13 and walking 8, with 4 home runs given up. Opposing him is Janson Junk for Miami, who enters at 0-2 with a 4.50 ERA and 1.32 WHIP over 22 innings. Junk has allowed 23 hits, struck out 15, walked 6, and surrendered 2 home runs, showing slightly more control in his outings so far.
Cardinals Looking to Regain Momentum on the Road
St. Louis enters this matchup with a 13-9 record and a solid 6-4 mark on the road. The Cardinals have been playing well overall despite recently losing to Miami 5-3. Prior to that, they had built momentum with consecutive wins, recently winning over Houston multiple times and also securing a victory against Cleveland. That recent stretch shows they are capable of stringing together strong performances, even if the latest result went against them.
Offensively, the Cardinals are hitting .230 as a team with 106 runs scored and 25 home runs. Their .325 on-base percentage and .373 slugging percentage indicate a lineup that can produce but has been somewhat inconsistent. On the pitching side, the team holds a 4.86 ERA and 1.42 WHIP, while allowing a .253 opponent batting average. They have also recorded 140 strikeouts while issuing 90 walks.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
One key concern for St. Louis is the pitching staff’s overall effectiveness. The 4.86 ERA and 1.42 WHIP suggest that opponents are consistently finding opportunities to score, and that has put added pressure on the offense to keep pace.
Marlins Finding Their Groove at Home
Miami comes into this game with an 11-12 record but has been particularly strong at home with a 9-5 mark. The Marlins recently won over St. Louis 5-3 and also secured another victory against Milwaukee. While they had a brief stretch of losses prior to that, the recent wins suggest they are starting to find a rhythm, especially in their home environment.
The Marlins are hitting .254 as a team with 105 runs scored and 16 home runs. Their .330 on-base percentage and .391 slugging percentage highlight a balanced offensive approach. On the mound, Miami has posted a 4.01 ERA and a 1.25 WHIP, while limiting opponents to a .216 batting average. They have also recorded 203 strikeouts, which stands out as a strong indicator of their pitching staff’s ability to generate outs.
A major strength for Miami has been its pitching efficiency. The lower opponent batting average and solid WHIP show that they are doing a better job of limiting baserunners compared to their opponent in this matchup.
St. Louis Cardinals vs Miami Marlins Picks and Prediction
St. Louis Cardinals vs Miami Marlins Pick
Pick: Miami Marlins Moneyline
Miami enters this game with the edge in both pitching efficiency and home performance. The Marlins’ lower ERA, better WHIP, and ability to limit opposing hitters give them a noticeable advantage, especially against a Cardinals pitching staff that has allowed more traffic on the bases. With Miami already recently winning over St. Louis and performing well at home, the consistency on the mound becomes a key factor. While the Cardinals have shown flashes offensively, the Marlins’ pitching metrics suggest they are better positioned to control this matchup.
St. Louis Cardinals vs Miami Marlins Total Pick
Pick: Under 8.5
I’m leaning toward the under in this game based on Miami’s ability to suppress opposing offenses with a .216 opponent batting average. While St. Louis has shown the ability to score, their inconsistency combined with Miami’s pitching efficiency points toward a more controlled game. Both teams have also recently played a 5-3 contest, which fits within this total range. With Miami’s pitching showing stronger control overall, I expect scoring to stay limited.
Final Score Prediction: Miami Marlins 5 – St. Louis Cardinals 3
This prediction was written before the completion of game play on Tuesday.
Never Tried Picks and Parlays? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code BUCK
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!
