St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions for Friday, September 12, 2025
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Cardinals vs Brewers Game Information
The Saint Louis Cardinals will be on the road Friday night for game 1 of 3 in Milwaukee with a game at American Family Field against the Milwaukee Brewers at 8:10 PM. Saint Louis is a few games below .500 on the year, currently 4th in the National League Central. The Milwaukee Brewers return home Friday night, as the best team in baseball, 31 games above .500, following a three-game losing streak on the road in Texas. Stay on the action with our MLB Picks.
Cardinals Preview
Alec Burleson leads the Saint Louis offense this season with a .282 batting average. Wilson Contreras has boasted a team-leading twenty home runs and 78 RBIs this season for the Cardinals. As a team, Saint Louis has a .244 batting average and has scored 629 runs on 1206 hits. The Saint Louis bullpen has been shaky this season with a 4.26 team ERA.
Brewers Preview
Sal Frelic leads the Milwaukee offense this season with a .294 batting average. Christian Yelich leads the team with 27 home runs and 93 RBIs this season. The Milwaukee Brewers have been solid offensively this season with a .260 batting average and have scored 743 runs on 1300 hits. The Milwaukee power has been outstanding with 157 home runs and a .408 team slugging percentage.
Cardinals vs Brewers Pitching Matchup
Andre Pallante will take the mound Thursday for Saint Louis with six wins and 13 losses this season alongside a 5.28 ERA across 150 innings of work. Milwaukee will send out Quinn Priester, who has twelve wins and two losses this season, to go along with the 3.25 ERA across 141.1 innings of work.
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Cardinals vs Brewers Pick
The Milwaukee Brewers are a much better team in this matchup and will get back to their winning ways on Friday. Look for Milwaukee to control this game from the onset as their offense and elite pitching will do the job. Take the Brewers Friday night to start their new series at home with a win and cover against the Cardinals.
Pick: Milwaukee Brewers -1.5
Secondary: Over Under
Lean: Christian Yelich RBI
Final Score Prediction: Milwaukee Brewers win and cover 6-1.
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