St.Louis Cardinals vs Milwaukee Brewers Picks and Predictions for Saturday, September 26th, 2026
St. Louis Cardinals vs Milwaukee Brewers Game Information
The Saint Louis Cardinals will stay on the road Saturday afternoon with a 7:10 PM matchup in Milwaukee against the Milwaukee Brewers. Saint Louis is below .500 coming into this matchup, having already been eliminated from playoff contention. The Milwaukee Brewers remain at home on Saturday with more than 100 wins this season as the top team in baseball after securing the National League Central title. Stay up to date with our MLB Picks.
St. Louis Cardinals Preview
Kyle Leahy got the start for Saint Louis in their last outing, giving up 1 run on 3 hits across 2 innings, resulting in the loss. The Saint Louis bullpen was solid enough, but they gave up one run on four hits over the final 6 innings, leading to the loss. Alec Burleson led the Cardinals offense in their last game with 1 hit and 1 run driven in.
Milwaukee Brewers Preview
Shane Drohan started Milwaukee's last game, giving up one run on three hits across 2.2 innings, resulting in a no-decision. The Milwaukee bullpen was phenomenal, giving up no runs on no hits over the final 6.1 innings to secure the win. Milwaukee had a balanced attack in its last game against Philadelphia, with 5 different players driving in 1 run each.
St. Louis Cardinals vs Milwaukee Brewers Pitching Matchup
Quinn Mathews is scheduled to start for St. Louis against Milwaukee's Dustin May. Mathews enters Saturday at 2-3 with a 3.65 ERA, giving the Cardinals a solid option on the mound. May is 7-9 with a 4.67 ERA and 139 strikeouts for Milwaukee. Mathews owns the better ERA, meaning Milwaukee doesn't have the same starting-pitching advantage that its overall record might suggest.
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St. Louis Cardinals vs Milwaukee Brewers Pick
Mathews gives St. Louis a chance to keep the game close early. Milwaukee, however, has been the much stronger club throughout the season and has reached the 100-win mark. The Brewers also get the advantage of playing at American Family Field. May needs to limit damage and avoid putting Milwaukee into an early hole, but the Brewers' offense and overall depth should provide enough support. Expect St. Louis to hang around before Milwaukee eventually breaks through during the middle or later innings.
- Pick: Milwaukee Brewers
- Secondary: Milwaukee Brewers Moneyline
- Lean: Under
Final Score Prediction: Milwaukee Brewers win 5-3
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