St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions for Sunday September 14 2025

By: Jeremy O'Quinn Published 09/14/2025, 12:30 AM ET
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Cardinals Preview

The St. Louis Cardinals are heading to American Family Field on Sunday, where they will take on the Milwaukee Brewers. Get the rest of our free MLB picks here! The Cardinals currently sit fourth in the NL Central, as they enter this game with a 72-76 record. St. Louis has now dropped four straight games, most recently suffering an 8-2 loss against the Brewers on Friday. Miles Mikolas will be the starting pitcher for the Cardinals in this game, he has a 4.84 ERA to go along with his 7-10 record. St. Louis is averaging 8.4 hits and 4.3 runs per game. The Cardinals have allowed 8.8 hits and 4.7 runs per game.

Brewers Preview

The Milwaukee Brewers currently sit first in the NL Central, entering this game with a 90-58 record. Milwaukee picked up a much-needed win on Friday, taking down the Cardinals 8-2. Jacob Misiorowski will be the Brewers’ starting pitcher in this game, he’s posted a 4.09 ERA to go along with his 5-2 record. Milwaukee is putting up 8.9 hits and 5.1 runs per game while batting .260. The Brewers’ pitching staff has been among the best in baseball this season, allowing roughly 7.7 hits and 3.9 runs per game

Cardinals vs Brewers Pick

St. Louis is hoping to avoid their fifth consecutive loss, while the Brewers are looking to build off an 8-2 victory on Friday. Misiorowski has been sound for Milwaukee this season, expect his play to lead the Brewers to a win. Final score prediction, Brewers win 5-3 and cover the -1.5 spread.

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