St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions for Sunday, September 27th, 2026

St. Louis Cardinals vs Milwaukee Brewers Game Information

The St. Louis Cardinals will continue their road series Sunday night against the Milwaukee Brewers. St. Louis enters the weekend at 77-81 and sits below .500 in the National League Central. Milwaukee is 99-59 and enters Saturday one victory away from reaching 100 wins. For more MLB action, see our MLB Picks.

St. Louis Cardinals Preview

St. Louis enters Saturday with a .241 team batting average, scoring 710 runs on 1293 hits. The Cardinals have recorded a .314 OBP and a .379 team slugging percentage while hitting 162 home runs. St. Louis has generated enough offense to score more than 700 runs but has lacked the consistency necessary to remain in contention in the NL Central.

Milwaukee Brewers Preview

Milwaukee comes into this matchup with a .258 team batting average, producing 815 runs on 1392 hits. The Brewers have posted an impressive .340 OBP and a .402 team slugging percentage while hitting 152 home runs. Milwaukee has scored more than 100 additional runs than St. Louis despite hitting fewer home runs, showing how consistently the Brewers have put runners on base and generated offense.

St. Louis Cardinals vs Milwaukee Brewers Pitching Matchup

Andre Pallante will be on the mound Sunday for Saint Louis. Pallante is 12-8 this year with a 3.61 ERA across 157 innings. Jacob Misiorowski counters for the Brewers. Misiorowski is 15-5 with a 1.86 ERA through 169.1 innings.

St. Louis Cardinals vs Milwaukee Brewers Pick

Milwaukee has a substantial offensive advantage in this matchup. The Brewers have the better batting average, OBP, and slugging percentage while producing more than 800 runs. St. Louis has slightly more home-run power, but Milwaukee has been far better at generating consistent offense. Look for the Brewers to move to 100 victories with another home win.

• Pick: Milwaukee Brewers
• Secondary: Milwaukee Brewers Run Line
• Lean: Milwaukee Brewers Team Total Over

Final Score Prediction: Milwaukee Brewers win 7-3

Game Written Before Completion of the Game on Saturday

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