St. Louis Cardinals vs New York Yankees Picks, Prediction, Odds, and Line Movement for Tuesday August 4 2026
Tuesday night's interleague clash between the St. Louis Cardinals and New York Yankees offers plenty for bettors to unpack, from moneyline value to run line adjustments and total movement. For bettors looking for more guidance across the league this week, our MLB picks page breaks down additional matchups. Below, we cover the odds, line movement, betting trends, injuries, and our full side, total, and final score predictions for this Yankee Stadium matchup.
TLDR: Quick Picks and Prediction
- Spread Pick: New York Yankees -1.5 (+119)
- Total Pick: Under 8 runs
- Projected Final Score: Yankees 5, Cardinals 2
Odds and Line Movement
New York opened as a heavy moneyline favorite at -175, with St. Louis available at +144. The Yankees are also priced at -1.5 on the run line at +119, while the Cardinals sit at +1.5 (-143). The total for this matchup is set at eight runs. Below is a look at the current odds snapshot followed by full line movement tracked from Monday night through Tuesday morning.
Current Odds
| Date | Time | St. Louis (ML) | NY Yankees (ML) | Total (O/U) | Public ($, #) |
|---|---|---|---|---|---|
| 08/04 | 00:18:02AM | +144 | -175 | 8o-118 / 8u-102 | NYY 90%, 86 |
Line Movement
| Date | Time | St. Louis | NY Yankees | Over | Under |
|---|---|---|---|---|---|
| 08/04 | 03:16:55AM | — | — | 8o-119 | 8u-101 |
| 08/04 | 00:18:02AM | +144 | -175 | 8o-118 | 8u-102 |
| 08/03 | 11:33:30PM | +144 | -175 | 8o-115 | 8u-104 |
| 08/03 | 11:30:10PM | — | — | 8o-116 | 8u-104 |
| 08/03 | 11:10:32PM | — | — | 8o-116 | 8u-103 |
| 08/03 | 11:09:49PM | +141 | -171 | 8o-117 | 8u-103 |
Cardinals vs Yankees Key Matchups and Game Preview
St. Louis improved to 56-57 by taking Monday's opener 13-7, getting three home runs from Alec Burleson and a seven-run eighth inning to overcome a brief New York comeback. The Yankees fell to 63-50 and have now lost three of their last five games.
Cardinals Starting Pitching
Hunter Dobbins will make the start for St. Louis with a 2-1 record, 3.74 ERA and 1.34 WHIP across 33.2 innings. His limited workload adds some uncertainty, but he has allowed only four home runs and issued 11 walks while recording 32 strikeouts.
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Yankees Starting Pitching
New York counters with Ryan Weathers, who owns a 4-7 record, 3.99 ERA and 1.24 WHIP through 115 innings. The left-hander is coming off seven scoreless innings in his previous appearance and has demonstrated better control than Dobbins over a much larger sample, producing 126 strikeouts against 33 walks.
St. Louis Lineup
Jordan Walker leads St. Louis with 22 homers and 81 RBI, while Burleson carries a team-best .288 average and enters with momentum from Monday's breakout performance.
New York Lineup
New York has the stronger overall pitching profile, ranking ahead of St. Louis in team ERA, WHIP, opponent batting average and strikeouts. The Yankees also hold a significant power advantage with 162 home runs compared to the Cardinals' 118, although several of their biggest bats remain unavailable.
Yankees Bullpen
Ben Rice has become even more important for the Yankees during their injury issues, leading the club with 31 home runs and 73 RBI while posting a .263 average and .556 slugging percentage. Weathers' strikeout-to-walk profile and recent form give New York the starting-pitching edge, and the Yankees should respond after being embarrassed in the opener.
Betting Trends: STL vs NYY
Public money is heavily on New York in this spot, with 90% of moneyline tickets and 86% of moneyline handle on the Yankees as of the latest snapshot, up from 61% and 75% earlier in the series. On the total, the public has leaned Under recently at 88% tickets and 89% handle, a shift from an earlier snapshot showing 95% on the Over and 60% of handle also on the Over, suggesting significant movement in total sentiment across the two days.
Key Injuries and Things To Know: STL vs NYY
Cardinals Injuries
St. Louis is missing infielder Ramón Urías and pitcher Max Rajcic.
New York Injuries
Aaron Judge, Giancarlo Stanton and Cody Bellinger are all sidelined, removing a large amount of power and run-producing ability from the middle of the lineup. Carlos Rodón and Clarke Schmidt are also out, reducing New York's starting depth.
Cardinals vs Yankees Side and Over/Under Picks
Cardinals Side Pick
The depleted lineup makes laying -175 unattractive on the Yankees moneyline, but New York offers better value on the run line.
NYY Value Play
Take the Yankees -1.5 at +119, banking on the improved starting pitching matchup and a bounce-back effort after Monday's blowout loss.
Yankees Run Line Angle
- Spread Pick: New York Yankees -1.5 (+119)
- Total Pick: Under 8 runs
Final Score Prediction
- New York Yankees: 5 runs
- St. Louis Cardinals: 2 runs
- Final Score: Yankees 5, Cardinals 2
How to Wager On Cardinals vs Yankees
Bettors looking to back the Yankees run line or the Under in this Cardinals-Yankees matchup have a variety of tools available for finding the best number and staying disciplined with bankroll management. For data-driven guidance on spreads and totals like tonight's game, check out our AI picks breakdown. If you want a deeper look at model-based projections for run line value specifically, the Dimers review covers how that platform grades matchups like this one. For bettors comparing totals models before locking in the Under, the Oddible review is another resource worth checking before placing a wager on tonight's Cardinals-Yankees total.
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