St. Louis Cardinals vs New York Yankees Picks, Prediction, Odds, and Line Movement for Wednesday August 5 2026

By: Kyle Kargel Published 08/05/2026, 08:52 AM ET
Cardinals vs Yankees picks

The St. Louis Cardinals and New York Yankees settle their three-game series on Wednesday, August 5, with first pitch scheduled for 7:05 p.m. ET in the Bronx. With the series tied 1-1 heading into the rubber match, bettors looking for more MLB predictions will want to see how the moneyline, run line and total have moved given New York's banged-up lineup and a pitching matchup that favors contact suppression over power.

TLDR: Quick Picks and Prediction

  • Total: Under 8.5
  • Moneyline lean: New York -146
  • Projected Final Score: Yankees 4, Cardinals 3

Odds and Line Movement

New York has held steady as the favorite throughout the day, with the moneyline moving only slightly from its opening number. The total has also stayed close to 8.5 for most of the betting window, with the under drawing significant public backing as first pitch approaches.

Current Odds

Date Time St. Louis NY Yankees Total Public ($, #)
08/05 01:33:16AM +129 -156 8œo-121 / 8œu-101 NYY 89%, 79%

Line Movement - Moneyline

Date Time St. Louis NY Yankees Public ($, #)
08/05 01:33:16AM +129 -156 NYY 89%, 79%
08/05 01:33:16AM +129 -156 NYY 78%, 78%
08/04 11:30:34PM +129 -156 NYY 77%, 78%
08/04 11:30:34PM +129 -156 NYY 93%, 82%
08/04 11:29:34PM +126 -152 NYY 93%, 82%
08/04 06:46:53PM +129 -156 —
08/04 06:46:53PM +129 -156 NYY 92%, 94%
08/04 04:39:34PM +123 -149 —
08/04 04:39:34PM +123 -149 —

Line Movement - Total

Date Time Over Under Public ($, #)
08/05 01:33:16AM 8œo-121 8œu-101 U88%, U90%
08/04 11:30:34PM 9o+102 9u-123 U88%, U90%
08/04 11:29:34PM 9o-101 9u-119 U88%, U90%
08/04 10:34:44PM 8œo-123 8œu+102 U88%, U90%
08/04 09:27:54PM 9o+102 9u-123 U94%, U92%
08/04 09:25:53PM 9o+101 9u-122 U88%, U89%
08/04 05:16:14PM 9o+100 9u-121 —
08/04 04:39:34PM 8œo-126 8œu+104 —

Cardinals vs Yankees: Key Matchups and Game Preview

The series is tied 1-1 after the Cardinals won the opener 13-7 and the Yankees answered with a 2-0 shutout, setting up a clear contrast between the explosive first game and the pitching-controlled second in the rubber match.

Andre Pallante on the Mound for St. Louis

St. Louis sends Andre Pallante to the mound with an 11-6 record, a 3.72 ERA and a 1.22 WHIP across 118.2 innings. Pallante has allowed 111 hits, struck out 86 and walked 34 while surrendering only 10 home runs, giving the Cardinals a starter who generally limits damaging contact.

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Will Warren Takes the Ball for New York

New York counters with Will Warren, who is 8-5 with a 4.14 ERA and a 1.36 WHIP in 108.2 innings. Warren has permitted 112 hits and 15 home runs, but his 109 strikeouts provide more swing-and-miss upside than Pallante.

Yankees Power Depleted by Injuries

The Yankees hold the broader team advantage, entering 64-50 compared with St. Louis at 56-58, with a pitching staff that owns a 3.34 ERA, a 1.19 WHIP and a .226 opponent batting average. Offensively, New York has produced 521 runs and 164 home runs with a .413 slugging percentage. Ben Rice has become the centerpiece of the available lineup, leading the club with 31 home runs and 73 RBIs while batting .262 with a .353 on-base percentage and a .553 slugging percentage. However, New York's injury list is significant, with Aaron Judge, Giancarlo Stanton and Cody Bellinger all sidelined, removing a substantial amount of power from the lineup.

Cardinals Lean on Walker and Burleson

St. Louis has posted a 4.15 ERA, a 1.34 WHIP and a .253 opponent average as a staff, and offensively the club has 496 runs, 118 home runs and a .379 slugging mark. Jordan Walker has 22 home runs, 81 RBIs and a .285 average, though his day-to-day designation makes his status important to monitor. Alec Burleson adds a .288 average and a .351 OBP to the middle of the order.

  • The series is tied 1-1, with the Cardinals winning the opener 13-7 and the Yankees answering with a 2-0 shutout.
  • Public money has heavily favored the Yankees on the moneyline, reaching as high as 93% of dollars wagered at points.
  • The total has drawn consistent public support on the under, with backing as high as 94% of dollars wagered.
  • New York holds the team pitching edge with a 3.34 ERA and a 1.19 WHIP compared to St. Louis' 4.15 ERA and 1.34 WHIP.
  • The Yankees have produced more runs and home runs as a team, but their injury situation is far more significant than St. Louis' heading into Wednesday.

Key Injuries and Things to Know: STL vs NYY

  • New York is without Aaron Judge, Giancarlo Stanton and Cody Bellinger, removing a substantial amount of power from the lineup.
  • Carlos Rodon and Clarke Schmidt are also unavailable from the Yankees rotation.
  • St. Louis' Jordan Walker is day-to-day, making his availability important for the Cardinals offense.
  • New York's injury situation makes the Yankees run line less appealing despite their superior season-long profile.

Cardinals vs Yankees Side and Over/Under Picks

  • Spread Lean: Cardinals +1.5 (fade the Yankees run line)
  • Total Pick: Under 8.5
  • Moneyline Lean: New York -146

The preferred wager is the under 8.5, banking on Pallante's home-run suppression, Warren's strikeout ability and New York's depleted lineup. The side lean is the Yankees moneyline rather than the run line, given how much power New York is missing from its everyday group.

Final Score Prediction: Yankees vs Cardinals

  • New York 4, St. Louis 3
  • Winning Side: Yankees Moneyline
  • Total: Under 8.5

How to Wager on Yankees vs Cardinals

Bettors building out this card have a couple of strong angles. The Yankees moneyline offers a safer path than the run line given New York's missing power bats, while the under 8.5 pairs well with Pallante's contact suppression and a lineup that has lost several key run producers. For bettors who want an extra layer of analysis before placing a wager on this game or any other MLB matchup, it is worth checking out AI picks for model-driven projections, along with the Dimers review and the Oddible review for additional data-backed perspectives on tonight's Yankees vs Cardinals matchup.

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