St Louis Cardinals Vs San Francisco Giants Pick and Prediction for Wednesday, September 24, 2025

By: Ricky Mackenzie Published 09/24/2025, 12:55 AM ET

Cardinals Preview

The Cardinals and Giants face off Wednesday night with identical 77-80 records, each team clinging to pride in a disappointing season. Get our free MLB Picks all season long! With the postseason out of reach, both clubs are looking to end strong and evaluate talent heading into 2026. The pitching matchup features veterans Sonny Gray for St. Louis and Robbie Ray for San Francisco.

Gray brings a solid 14-8 record to the mound, but his 4.33 ERA and 1.23 WHIP show some inconsistency. He’s been serviceable, striking out 194 in 174.2 innings, but has also been prone to giving up runs in bunches. Against a Giants team that can string together hits, command will be key.

Giants Preview

On the other side, Ray boasts a slightly better ERA at 3.65 and a strong 186 strikeouts over 182.1 innings. His walk rate is still high, but his ability to work out of jams has kept San Francisco in games all year. If his fastball location holds up, he’ll be tough on a streaky Cardinals lineup.

Giants vs Cardinals Pick

Both sides are playing loose with nothing to lose, which often leads to high-energy baseball. The deciding factor may be bullpen depth and late-game defense-areas where San Francisco holds a slight edge.

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Robbie Ray’s consistency on the mound gives San Francisco a slight edge in this evenly matched showdown. With both clubs out of playoff contention, expect a competitive but relaxed game. The Giants’ stronger bullpen and home-field energy should prove just enough to edge out the Cardinals in a close finish. Final Score Prediction, San Francisco Giants win 3-2.

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