St. Louis Cardinals vs San Francisco Giants Picks and Prediction for Tuesday September 23 2025
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The San Francisco Giants remain at home on Tuesday with the St. Louis Cardinals in town. The Giants and the Cardinals both sit 4 games back for the last National League Wildcard position. The Cardinals beat the Giants 4-3 in their last meeting earlier this month. San Francisco is a -193 favorite and the total is set at 7.5 runs. Stay up to date with our expert's MLB Predictions.
San Francisco Giants Preview
The San Francisco Giants are 77-79 on the season and they sit 4th in the NL West. The Giants have won three of their last ten games and they carry a 38-37 home field record. San Francisco is averaging 4.3 runs scored per game with 7.8 hits. Heliot Ramos leads the Giants on the season with 152 hits. Logan Webb will make his 33rd start on the mound for San Francisco. Webb is 14-11 on the season with 195.2 innings pitched. Webb has 211 strikeouts and carries a 3.27 ERA. Webb pitched 7 innings in his last start allowing 4 hits and 1 earned run. The San Francisco Giants carry a 3.85 team ERA.
St. Louis Cardinals Preview
The St. Louis Cardinals are 4th in the NL Central with a 76-80 record. The Cardinals have won four of their last ten games and they carry a 32-43 road record. St. Louis is averaging 8.2 hits per game and 4.3 runs scored. Alec Burleson leads the Cardinals on the season with 138 hits. Andre Pallante will make his 31st start on the hill for the St. Louis Cardinals. Pallante is 6-15 on the season and carries a 5.29 ERA. Pallante pitched 5 innings in each of his last two starts giving up 4 earned runs in both games. The St. Louis Cardinals carry a 4.23 team ERA.
Giants vs Cardinals Free Picks & Prediction
The San Francisco Giants are heavy favorites in this matchup on Tuesday. Andre Pallante takes the mound for the Cardinals who has struggled most of the season. Pallante has allowed 12 earned runs over his last four starts. Both teams are in desperation mode to try to see some post season action. The value is in the total.
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- Final Score Prediction: San Francisco Giants win 7-4 but the play is on the OVER.
Giants vs Cardinals Best Free Picks:
- San Francisco Giants -1.5 runs
- OVER 7.5 runs
